Abstract

The human and animal osmoregulation system is aimed at stabilizing serum osmolality in order to maintain cell volume. It has been shown that the introduction of 5 mL water per 100 g of body weight into the stomach of rats decreases serum osmolality and the concentration of Na and Ca, but not K and Mg. The cascade system of osmotic homeostasis increases secretion of glucagon-like peptide-1 (GLP-1) and oxytocin, and decreases secretion of vasopressin, which reduces the osmotic permeability of collecting duct. After water loading and the injection of 0.015 nM exenatide (GLP-1 mimetic), the time of excretion of 50% of water was halved from 112 ± 4 to 57 ± 5 min (p < 0.01), and after the injection of 0.015 nM oxytocin, it decreased to 83 ± 6 min (p < 0.01). The physiological mechanism of renal effect of the aforementioned hormones which accelerate the recovery of osmotic homeostasis has been found.

中文翻译：

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渗透稳态调节的级联系统。

摘要

人和动物渗透调节系统旨在稳定血清渗透压，以维持细胞体积。已经表明，每100克体重向大鼠的胃中加入5毫升水可降低血清渗透压和Na和Ca的浓度，但不能降低K和Mg的浓度。渗透稳态的级联系统增加了胰高血糖素样肽1（GLP-1）和催产素的分泌，并降低了加压素的分泌，从而降低了收集管的渗透性。加水并注入0.015 nM艾塞那肽（GLP-1模拟物）后，排泄50％水的时间从112±4分钟减至57±5分钟（p <0.01），而注入0.015 nM之后催产素下降到83±6分钟（p<0.01）。已经发现上述激素的肾脏作用的生理机制，其促进渗透性稳态的恢复。