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The Cascade System of Osmotic Homeostasis Regulation.
Doklady Biological Sciences Pub Date : 2020-04-27 , DOI: 10.1134/s0012496620010056
Yu V Natochin 1 , A S Marina 1 , E I Shakhmatova 1
Affiliation  

Abstract

The human and animal osmoregulation system is aimed at stabilizing serum osmolality in order to maintain cell volume. It has been shown that the introduction of 5 mL water per 100 g of body weight into the stomach of rats decreases serum osmolality and the concentration of Na and Ca, but not K and Mg. The cascade system of osmotic homeostasis increases secretion of glucagon-like peptide-1 (GLP-1) and oxytocin, and decreases secretion of vasopressin, which reduces the osmotic permeability of collecting duct. After water loading and the injection of 0.015 nM exenatide (GLP-1 mimetic), the time of excretion of 50% of water was halved from 112 ± 4 to 57 ± 5 min (p < 0.01), and after the injection of 0.015 nM oxytocin, it decreased to 83 ± 6 min (p < 0.01). The physiological mechanism of renal effect of the aforementioned hormones which accelerate the recovery of osmotic homeostasis has been found.



中文翻译:

渗透稳态调节的级联系统。

摘要

人和动物渗透调节系统旨在稳定血清渗透压,以维持细胞体积。已经表明,每100克体重向大鼠的胃中加入5毫升水可降低血清渗透压和Na和Ca的浓度,但不能降低K和Mg的浓度。渗透稳态的级联系统增加了胰高血糖素样肽1(GLP-1)和催产素的分泌,并降低了加压素的分泌,从而降低了收集管的渗透性。加水并注入0.015 nM艾塞那肽(GLP-1模拟物)后,排泄50%水的时间从112±4分钟减至57±5分钟(p <0.01),而注入0.015 nM之后催产素下降到83±6分钟(p<0.01)。已经发现上述激素的肾脏作用的生理机制,其促进渗透性稳态的恢复。

更新日期:2020-04-27
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