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The neuroprotective effect of Riparin IV on oxidative stress and neuroinflammation related to chronic stress-induced cognitive impairment.
Hormones and Behavior ( IF 2.5 ) Pub Date : 2020-04-28 , DOI: 10.1016/j.yhbeh.2020.104758
Raquell de Castro Chaves 1 , Auriana Serra Vasconcelos Mallmann 1 , Natália Ferreira de Oliveira 1 , Victor Celso Cavalcanti Capibaribe 1 , Daniel Moreira Alves da Silva 1 , Iardja Stéfane Lopes 1 , José Tiago Valentim 1 , Giovanna Riello Barbosa 2 , Alyne Mara Rodrigues de Carvalho 1 , Marta Maria de França Fonteles 3 , Stanley Juan Chavez Gutierrez 4 , José Maria Barbosa Filho 5 , Francisca Cléa Florenço de Sousa 1
Affiliation  

BACKGROUND Cognitive impairment is identified as one of the diagnostic criteria for major depressive disorder and can extensively affect the quality of life of patients. Based on these findings, this study aimed to investigate the possible effects of Riparin IV (Rip IV) on cognitive impairment induced by chronic administration of corticosterone in mice. METHODS Female Swiss mice were divided into four groups: control (Control), corticosterone (Cort), Riparin IV (Cort + Rip IV), and Fluvoxamine (Cort + Flu). Three groups were administered corticosterone (20 mg/kg) subcutaneously during the 22-day study, while the control group received only vehicle. After the 14th day, the groups were administered medications: Riparin IV (Rip IV), fluvoxamine (Flu), or distilled water, by gavage, 1 h after the subcutaneous injections. After treatment, mice underwent behavioral testing, and brain areas were removed for oxidative stress and cytokine content assays. RESULTS The results revealed that Cort-treated mice developed a cognitive impairment and exhibited a neuroinflammatory profile with an oxidative load and Th1/Th2 cytokine imbalance. Rip IV treatment significantly ameliorated the cognitive deficit induced by Cort and displayed a neuroprotective effect. CONCLUSION The antidepressant-like ability of Rip IV treatment against chronic Cort-induced stress may be due to its potential to mitigate inflammatory damage and oxidative stress. The antioxidant and anti-inflammatory effect observed indicates Rip IV as a possible drug for antidepressant treatment of non-responsive patients with severe and cognitive symptoms.

中文翻译:

肝素IV对与慢性应激引起的认知障碍有关的氧化应激和神经炎症的神经保护作用。

背景技术认知障碍被确定为重度抑郁症的诊断标准之一,并且可以广泛影响患者的生活质量。基于这些发现,本研究旨在研究Riparin IV(Rip IV)对小鼠长期服用皮质酮引起的认知障碍的可能影响。方法将瑞士雌性小鼠分为四组:对照组(对照组),皮质酮(麦芽汁),Riparin IV(麦芽汁+ Rip IV)和氟伏沙明(麦芽汁+流感)。在为期22天的研究中,三组皮下注射了皮质酮(20 mg / kg),而对照组仅接受了溶媒。在第14天后,在皮下注射1小时后,通过管饲法向各组给药:Riparin IV(Rip IV),氟伏沙明(Flu)或蒸馏水。治疗后,对小鼠进行行为测试,并去除大脑区域进行氧化应激和细胞因子含量测定。结果结果表明,用Cort治疗的小鼠出现了认知障碍,并表现出具有氧化负荷和Th1 / Th2细胞因子失衡的神经炎症。Rip IV治疗显着改善了Cort诱导的认知缺陷,并表现出神经保护作用。结论Rip IV治疗抗慢性Cort诱导的应激的抗抑郁能力可能归因于其减轻炎症损伤和氧化应激的潜力。观察到的抗氧化和抗炎作用表明,Rip IV可作为具有严重和认知症状的非反应性患者抗抑郁治疗的可能药物。去除大脑区域以进行氧化应激和细胞因子含量测定。结果结果表明,用Cort治疗的小鼠出现了认知障碍,并表现出具有氧化负荷和Th1 / Th2细胞因子失衡的神经炎症。Rip IV治疗显着改善了Cort诱导的认知缺陷,并表现出神经保护作用。结论Rip IV治疗抗慢性Cort诱导的应激的抗抑郁能力可能归因于其减轻炎症损伤和氧化应激的潜力。观察到的抗氧化和抗炎作用表明,Rip IV可作为具有严重和认知症状的非反应性患者抗抑郁治疗的可能药物。去除大脑区域以进行氧化应激和细胞因子含量测定。结果结果表明,用Cort治疗的小鼠出现了认知障碍,并表现出具有氧化负荷和Th1 / Th2细胞因子失衡的神经炎症。Rip IV治疗显着改善了Cort诱导的认知缺陷,并显示出神经保护作用。结论Rip IV治疗抗慢性Cort诱导的应激的抗抑郁能力可能归因于其减轻炎症损伤和氧化应激的潜力。观察到的抗氧化和抗炎作用表明,Rip IV可作为抗抑郁药用于治疗具有严重和认知症状的无反应患者的抗抑郁药。结果结果表明,用Cort处理的小鼠表现出认知障碍,并表现出具有氧化负荷和Th1 / Th2细胞因子失衡的神经炎症。Rip IV治疗显着改善了Cort诱导的认知缺陷,并表现出神经保护作用。结论Rip IV治疗抗慢性Cort诱导的应激的抗抑郁能力可能归因于其减轻炎症损伤和氧化应激的潜力。观察到的抗氧化和抗炎作用表明,Rip IV可作为具有严重和认知症状的非反应性患者抗抑郁治疗的可能药物。结果结果表明,用Cort治疗的小鼠出现了认知障碍,并表现出具有氧化负荷和Th1 / Th2细胞因子失衡的神经炎症。Rip IV治疗显着改善了Cort诱导的认知缺陷,并表现出神经保护作用。结论Rip IV治疗抗慢性Cort诱导的应激的抗抑郁能力可能归因于其减轻炎症损伤和氧化应激的潜力。观察到的抗氧化和抗炎作用表明,Rip IV可作为具有严重和认知症状的非反应性患者抗抑郁治疗的可能药物。Rip IV治疗显着改善了Cort诱导的认知缺陷,并表现出神经保护作用。结论Rip IV治疗抗慢性Cort诱导的应激的抗抑郁能力可能归因于其减轻炎症损伤和氧化应激的潜力。观察到的抗氧化和抗炎作用表明,Rip IV可作为抗抑郁药用于治疗具有严重和认知症状的无反应患者的抗抑郁药。Rip IV治疗显着改善了Cort诱导的认知缺陷,并表现出神经保护作用。结论Rip IV治疗抗慢性Cort诱导的应激的抗抑郁能力可能归因于其减轻炎症损伤和氧化应激的潜力。观察到的抗氧化和抗炎作用表明,Rip IV可作为具有严重和认知症状的非反应性患者抗抑郁治疗的可能药物。
更新日期:2020-04-27
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