OBJECTIVE Hypoventilation and carbon dioxide (CO2) retention are common during sedation. The current study investigated the ventilation responses to nasal high flow (NHF) during sedation with propofol. METHODS NHF of 30 L/min and 60 L/min with room air was applied during wakefulness and sedation in 10 male volunteers. Ventilation was monitored by respiratory inductance plethysmography, transcutaneous partial pressure of CO2 (TcCO2), and SpO2. RESULTS During sedation, NHF of 30 L/min and 60 L/min reduced the TcCO2 by 2.9 ± 2.7 mmHg (p = 0.025) and by 3.6 ± 3.4 mmHg (p = 0.024) without affecting SpO2 and reduced the mean respiratory rate by 3 ± 3 breaths/min (p = 0.011) and by 4 ± 3 breaths/min (p = 0.003), respectively. CONCLUSION During sedation with propofol, NHF without supplemental oxygen attenuated CO2 retention and reduced the respiratory rate. The findings show that NHF can improve ventilation during sedation, which may reduce the risk of complications related to hypoventilation.

中文翻译：

---

鼻高流量改善丙泊酚镇静期间的通气：一项在健康志愿者中进行的随机交叉研究。

目的 镇静期间通气不足和二氧化碳 (CO2) 滞留很常见。目前的研究调查了丙泊酚镇静期间对鼻高流量 (NHF) 的通气反应。方法 10 名男性志愿者在清醒和镇静期间使用 30 L/min 和 60 L/min 的 NHF 和室内空气。通过呼吸电感体积描记法、经皮 CO2 分压 (TcCO2) 和 SpO2 监测通气情况。结果 在镇静期间，30 L/min 和 60 L/min 的 NHF 将 TcCO2 降低了 2.9 ± 2.7 mmHg (p = 0.025) 和 3.6 ± 3.4 mmHg (p = 0.024) 而不会影响 SpO2，并且将平均呼吸频率降低了 3 ± 3 次呼吸/分钟 (p = 0.011) 和 4 ± 3 次呼吸/分钟 (p = 0.003)，分别。结论 在丙泊酚镇静期间，没有补充氧气的 NHF 减弱了 CO2 滞留并降低了呼吸频率。研究结果表明，NHF 可以改善镇静期间的通气，这可能会降低与通气不足相关的并发症的风险。