Abstract Potentilla anserina L. is not only a medicinal plant, but also a traditional cuisine. Hence, an acute toxicity study was performed to confirm its safety profile. Forty Kunming mice were randomly divided into two groups: control group and P. anserina L. extract group. Using the maximum dosage method, the P. anserina L. extract group was given the maximum dose within 12 h, equivalent to 345.6 g/kg crude drug. The control group was given distilled water. After administration, toxicity symptoms of mice were observed, body weight and food intake were recorded. After 14 days, blood was collected to measure biochemical parameters, autopsy was carried out to observe the changes of organs, and the vital organs were separated, weighed, and preserved for histopathological examination. The results showed that P. anserina L. extract group had no toxic symptoms. The activity, weight, and diet of mice were normal, and no abnormality was found in organ index, renal function, liver function, anatomical observation, and histopathological examination. Therefore, the maximum oral dosage (345.6 g/kg) of P. anserina L. was good safety. This study indicated that P. anserina L. had a large safety range and the clinical application was safe.

中文翻译：

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Potentilla anserina L.提取物对小鼠的急性毒性

摘要 Potentilla anserina L. 不仅是一种药用植物，也是一道传统美食。因此，进行了急性毒性研究以确认其安全性。40只昆明小鼠随机分为两组：对照组和鹅掌楸提取物组。采用最大剂量法，鹅掌楸提取物组在12 h内给予最大剂量，相当于345.6 g/kg生药。对照组给予蒸馏水。给药后，观察小鼠的毒性症状，记录体重和摄食量。14天后采血测定生化指标，进行尸检观察脏器变化，分离重要脏器，称重，保存组织病理学检查。结果表明，P. anserina L. 提取物组无中毒症状。小鼠活动、体重、饮食正常，脏器指标、肾功能、肝功能、解剖观察、组织病理学检查均未见异常。因此，P. anserina L. 的最大口服剂量（345.6 g/kg）具有良好的安全性。本研究表明P. anserina L.具有较大的安全范围，临床应用安全。