Abstract

Muriolide (1), a new aromatic lactone, has been isolated from the ethyl acetate fraction of Ranunculus muricatus. The compound was structurally characterized with the help of UV, IR, mass, 1D- and 2D-NMR data. It was tested in vitro for antioxidant and lipoxygenase inhibitory potential. Compound 1 showed good DPPH radical scavenging activity (IC₅₀=56.9 μM), however it was moderately active against lipoxygenase enzyme (IC₅₀=68.3 μM).

中文翻译：

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Muriolide，一种来自毛茛属植物的新型抗氧化内酯

摘要

Muriolide ( 1 ) 是一种新的芳香族内酯，已从毛茛的乙酸乙酯组分中分离出来。借助 UV、IR、质量、1D-和 2D-​​NMR 数据对化合物进行结构表征。它在体外测试了抗氧化和脂肪氧化酶抑制潜力。化合物1显示出良好的DPPH自由基清除活性(IC ₅₀ =56.9  μ M)，但是它对脂氧合酶具有中等活性(IC ₅₀ =68.3  μ M)。