Abstract

Background: Squamous cell lung carcinoma (SqCLC) is a type of non-small-cell lung cancer, accounting for 25–30% of all lung cancer cases with a median advanced stage survival of 8–11 months. Here we present a rare case of long-term survival with metastatic SqCLC following coil embolisation of the right pulmonary artery.

Case presentation: The 49-year-old patient was diagnosed with stage IV (cT4N3M1) SqCLC in 2007 due to a biopsy-proven central malignant tumour in the right lung and bilateral mediastinal lymphadenopathy. A magnetic resonance imaging scan also revealed a metastatic lesion in the liver. Soon after the diagnosis, the patient experienced pulmonary haemorrhage, which was managed by obturating the intermediate bronchus and performing coil embolisation of the right pulmonary artery. The patient also received chemotherapy in 2007 and 2009 without radiological changes. At three different time points in years 2010–2019, biopsies of the primary tumour were taken. All showed dense connective tissue with no indication of cancer growth. In 2020, a positron emission tomography scan showed no pathological metabolic activity in the lungs and liver. Currently, the patient remains in a stable clinical condition with a good performance status.

Conclusion: The long-term clinical benefit indicates a direct effect of coil embolisation on tumour progression. We suggest that coil embolisation of tumour-feeding arteries could be considered as a potential treatment method for patients with SqCLC.

摘要

背景：鳞状细胞肺癌（SqCLC）是一种非小细胞肺癌，占所有肺癌病例的25–30％，中位晚期生存期为8-11个月。在这里，我们介绍了罕见的右肺动脉线圈栓塞后转移性SqCLC长期生存的情况。

案例介绍：这位49岁的患者于2007年被诊断为IV期（cT4N3M1）SqCLC，原因是活检证实了右肺和双侧纵隔淋巴结肿大的中央恶性肿瘤。磁共振成像扫描还显示肝脏有转移性病变。诊断后不久，患者经历了肺出血，方法是通过阻塞中间支气管并进行右肺动脉的线圈栓塞治疗。该患者还于2007年和2009年接受了化疗，但无影像学改变。在2010-2019年的三个不同时间点，对原发肿瘤进行活检。全部显示出密集的结缔组织，没有癌症生长的迹象。2020年，正电子发射断层扫描显示肺和肝脏没有病理性代谢活动。目前，

结论：长期临床获益表明线圈栓塞对肿瘤进展具有直接作用。我们建议，将食道肿瘤的动脉栓塞栓塞考虑为SqCLC患者的一种潜在治疗方法。