1,2-Bis(4-pyridyl)ethane (bpa) and 1,2-bis(4-pyridyl)ethene (bpe) were used for the synthesis of polynuclear silver(I) complexes, {[Ag(bpa)]NO₃}_n (1), {[Ag(bpa)₂]CF₃SO₃^.H₂O}_n (2) and {[Ag(bpe)]CF₃SO₃}_n (3). In complexes 1–3, the corresponding nitrogen-containing heterocycle acts as a bridging ligand between two Ag(I) ions. In vitro antimicrobial activity of these complexes, along with the ligands used for their synthesis, was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and fungi. The silver(I) complexes 1–3 showed selectivity towards Candida spp. and Gram-negative Escherichia coli in comparison to the other investigated bacterial strains, effectively inhibiting the growth of four different Candida species with minimal inhibitory concentrations (MICs) between 2.5 and 25 μg/mL and the growth of E. coli, with MIC value being 12.5 μg/mL. Importantly, complex 2 significantly reduced C. albicans filamentation, an essential process for its pathogenesis. Antiproliferative effect on the normal human lung fibroblast cell line MRC-5 was also evaluated with the aim of determining the therapeutic potential of the complexes 1–3. The interactions of these complexes with calf thymus DNA (ctDNA) and bovine serum albumin (BSA) were studied to evaluate their binding activities towards these biomolecules for possible insights on their mode of action.

中文翻译：

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以 1,2-双(4-吡啶基)乙烷/乙烯作为桥连配体的多核银 (I) 配合物的抗菌活性和 DNA/BSA 结合亲和力。


1,2-双(4-吡啶基)乙烷(bpa)和1,2-双(4-吡啶基)乙烯(bpe)用于合成多核银(I)配合物{[Ag(bpa)]NO ₃ } _n ( 1 ), {[Ag(bpa) ₂ ]CF ₃ SO ₃ ^。 H ₂ O} _n ( 2 ) 和{[Ag(bpe)]CF ₃ SO ₃ } _n ( 3 )。在配合物1-3中，相应的含氮杂环充当两个 Ag(I) 离子之间的桥配体。针对广泛的革兰氏阳性和革兰氏阴性细菌和真菌，评估了这些复合物及其合成所用配体的体外抗菌活性。银 (I) 配合物1-3对念珠菌属具有选择性。与其他研究的细菌菌株相比，有效抑制四种不同念珠菌属的生长，最低抑菌浓度 (MIC) 在 2.5 至 25 μg /mL 之间，并且有效抑制大肠杆菌的生长，MIC 值为12.5μg /mL。重要的是，复合物2显着减少了白色念珠菌的丝状形成，这是其发病机制的一个重要过程。还评估了对正常人肺成纤维细胞系 MRC-5 的抗增殖作用，以确定复合物1-3的治疗潜力。研究了这些复合物与小牛胸腺 DNA (ctDNA) 和牛血清白蛋白 (BSA) 的相互作用，以评估它们对这些生物分子的结合活性，从而可能了解它们的作用模式。