The cysteine- perfluoroarene S_NAr reaction allows for the sequence-specific attachment of dyes and affinity tags to peptides and proteins. However, while many methods exist for the desulfuration of native and functionalized cysteine residues, there are no reports of their application to perfluoroarylated cysteines. Herein we report both the hydrogenolysis of a perfluoroarylated cysteine to alanine and elimination to dehydroalanine, reactions that are both accelerated by microwave irradiation.

中文翻译：

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微波辅助切割半胱氨酸全氟芳基硫醚。

所述半胱氨酸perfluoroarene小号_Ñ氩反应允许染料和亲和标记的肽和蛋白质的序列特异性附着。然而，尽管存在许多用于天然和功能化半胱氨酸残基脱硫的方法，但是没有报道将其应用于全氟芳基半胱氨酸。在本文中，我们既报道了全氟芳基化半胱氨酸的氢解成丙氨酸，又消除了脱氢丙氨酸，两者均通过微波辐照而加速反应。