It is expected that in 2050, there will be more than 20% of senior citizens aged over 60 years worldwide. Such alarming statistics require immediate attention to improve the health of the aging population. Since aging is closely related to the loss of antioxidant defense mechanisms, this situation eventually leads to numerous health problems, including fertility reduction. Furthermore, plant extracts have been used in traditional medicine as potent antioxidant sources. Although many experiments had reported the impact of various bioactive compounds on aging or fertility, there is a lack of review papers that combine both subjects. In this review, we have collected and discussed various bioactive compounds from 26 different plant species known to affect both longevity and fertility. These compounds, including phenolics and terpenes, are mostly involved in the antioxidant defense mechanisms of diverse organisms such as rats, mites, fruit flies, roundworms, and even roosters. A human clinical trial should be considered in the future to measure the effects of these bioactive compounds on human health and longevity. Ultimately, these plant-derived compounds could be developed into health supplements or potential medical drugs to ensure a healthy aging population.

预计到2050年，全球60岁以上的老年人口将超过20％。这种令人震惊的统计数据需要立即关注，以改善老龄化人口的健康状况。由于衰老与抗氧化剂防御机制的丧失密切相关，因此这种情况最终导致许多健康问题，包括生育力下降。此外，植物提取物已在传统医学中用作有效的抗氧化剂来源。尽管许多实验已经报道了各种生物活性化合物对衰老或生育能力的影响，但仍缺乏将这两个主题结合在一起的评论论文。在这篇综述中，我们已经收集并讨论了来自26种不同植物物种的各种生物活性化合物，这些物种已知会影响寿命和繁殖力。这些化合物，包括酚醛和萜烯，它们主要参与多种生物的抗氧化防御机制，例如大鼠，螨虫，果蝇，round虫甚至公鸡。将来应考虑进行人体临床试验，以测量这些生物活性化合物对人体健康和寿命的影响。最终，这些植物来源的化合物可以开发成健康补品或潜在的医学药物，以确保健康的老龄化人群。