Andrographolide: Synthetic Methods and Biological Activities.,Mini-Reviews in Medicinal Chemistry

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Andrographolide: Synthetic Methods and Biological Activities.
Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2020-09-30 , DOI: 10.2174/1389557520666200429100326
Meng Hao ₁ , Min Lv ₁ , Hui Xu _{1,

2}

Affiliation

Andrographolide, a labdane diterpenoid, is extracted and isolated from the plants of Andrographis paniculata. Andrographolide and its derivatives exhibited a wide range of biological properties, including anticancer activity, antibacterial activity, hepatoprotective activity, antiinflammatory activity, antiviral activity, antimalarial activity, antidiabetic activity, insecticidal activity, etc. As a continuation, this review aims at giving an overview of the recent advances (from 2015 to 2018) of andrographolide and its derivatives with regard to bioactivities, mechanisms of action, structural modifications, and structure-activity relationships.

中文翻译：

穿心莲内酯：合成方法和生物活性。

从穿心莲的植物中提取并分离出穿心莲内酯，一种拉丹烷二萜。穿心莲内酯及其衍生物具有广泛的生物学特性，包括抗癌活性，抗菌活性，保肝活性，抗炎活性，抗病毒活性，抗疟疾活性，抗糖尿病活性，杀虫活性等。作为综述，本综述旨在概述。穿心莲内酯及其衍生物在生物活性，作用机理，结构修饰和构效关系方面的最新进展（从2015年至2018年）。

更新日期：2020-11-12

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