The widely used antimalarial drug amodiaquine (AQ) contains a 7-Cl-quinoline unit, a substituted 4-aminophenol part connected through the amino group and a tertiary amine part. The 4-aminophenol unit can be easily oxidized through radical intermediates to iminoquinone. This reaction also takes place in vitro and in vivo enzymatic reactions. The reaction is expected to have an important role in degradation of AQ in surface waters and also during degradation in advanced oxidation processes. In this paper by means of radiation chemical techniques the one-electron oxidation and reduction of AQ were studied using transient kinetics, kinetics of AQ degradation, formation and decay of end-products of radical reactions. The hydroxyl radicals were shown to add both to the quinoline (∼ 38%) and aminophenol (∼ 50%) parts via formation of hydroxycyclohexadienyl radicals and by H-abstraction or by an electron removal from the tertiary amine part of the molecule (∼ 12%). The dihydroxycyclohexadienyl radical formed on the aminophenol part is suggested to transform to aminophenoxy radical. The hydrated electrons can also effectively contribute to AQ degradation. Chemical oxygen demand and total organic carbon content investigations were also made in order to characterize the ionizing radiation-induced oxidation and mineralization. In aerated 0.1 mmol dm⁻³ solution, at 2.5 kGy absorbed dose AQ and its higher molecular mass degradation products demolished completely. Ionizing irradiation is a capable technique for degradation of AQ under both oxidative and reductive circumstances.

广泛使用的抗疟药氨二喹（AQ）包含7-Cl-喹啉单元，通过氨基连接的取代的4-氨基苯酚部分和叔胺部分。4-氨基苯酚单元很容易通过自由基中间体氧化为亚氨基醌。该反应也发生在体外和体内酶促反应。预计该反应在地表水中AQ的降解以及高级氧化过程的降解中都将发挥重要作用。本文通过辐射化学技术，利用瞬变动力学，AQ降解动力学，自由基反应终产物的形成和衰减，研究了AQ的单电子氧化和还原。羟基自由基显示出两者添加到喹啉（〜38％）和氨基苯酚（〜50％）的部分经由形成羟基环己二烯基，并通过H吸收或从分子的叔胺部分除去电子（约12％）。建议在氨基酚部分上形成的二羟基环己二烯基转变为氨基苯氧基。水合电子还可以有效地促进AQ降解。还进行了化学需氧量和总有机碳含量的研究，以表征电离辐射诱导的氧化和矿化作用。在充气的0.1 mmol dm ^-3溶液中，在2.5 kGy的吸收剂量下AQ及其较高分子量的降解产物被完全清除。电离辐射是在氧化和还原条件下降解AQ的有效技术。