Abstract

Purpose: The present study retrospectively evaluated the feasibility, safety, and short-term efficacy of computed tomography (CT)-guided percutaneous microwave ablation (MWA) to treat multiple synchronous ground-glass opacities (GGOs) of the lung.

Materials and Methods: From October 2016 to May 2019, 33 patients (9 males and 24 females, mean age: 59.6 ± 10.0 years) with multiple GGOs (103 GGOs with mean size 12.3 ± 6.3 mm) were enrolled in this study. Patients underwent 66 procedures of CT-guided percutaneous MWA. The feasibility, safety, local progression-free survival, and overall survival were evaluated.

Results: The technical success and technique efficacy rate were 100% and no MWA procedure-related deaths were reported. The median follow-up period was 18.1 (range: 6.8–37.7) months. Major complications included pneumothorax (11/66, 16.7%), pleural effusion (2/66, 3.0%), pneumonia (3/66, 4.5%), and nerve injury (1/66, 1.5%), which were well controlled by appropriate treatment. Minor complications included pneumothorax (38/66, 57.6%), pleural effusion (43/66, 65.2%), hemoptysis (13/66, 19.7%), subcutaneous emphysema (4/66, 6.1%), and hemothorax (2/66, 3.0%). Currently, all patients are alive without local progression or tumor recurrence, despite the relatively insufficient follow-up time.

Conclusion: CT-guided percutaneous MWA for the treatment of multiple synchronous lung GGOs is feasible, safe, and efficacious over short-term follow-up. It may also be employed as an alternative approach for nonsurgical candidates. A longer follow-up is warranted to evaluate the oncologic outcomes.

摘要

目的：本研究回顾性评估了计算机断层扫描（CT）引导的经皮微波消融（MWA）治疗肺部多个同步磨玻璃混浊（GGO）的可行性，安全性和短期疗效。

材料与方法： 2016年10月至2019年5月，本研究纳入了33例多个GGO（103个平均大小为12.3±6.3 mm的GGO）的患者（男9例，女24例，平均年龄：59.6±10.0岁）。患者接受了66例CT引导的经皮MWA手术。评估了可行性，安全性，局部无进展生存期和总体生存期。

结果：技术成功率和技术有效率为100％，没有MWA手术相关死亡的报道。中位随访期为18.1个月（范围：6.8-37.7）个月。主要并发症包括气胸（11/66，16.7％），胸腔积液（2/66，3.0％），肺炎（3/66，4.5％）和神经损伤（1/66，1.5％）通过适当的治疗。次要并发症包括气胸（38/66，57.6％），胸腔积液（43/66，65.2％），咯血（13/66，19.7％），皮下气肿（4/66，6.1％）和血胸（2 / 66，3.0％）。目前，尽管随访时间相对不足，但所有患者均活着，没有局部进展或肿瘤复发。

结论： CT引导的经皮MWA治疗短期同步随访是可行，安全且有效的。它也可以用作非手术候选人的替代方法。有必要进行更长的随访以评估肿瘤学结局。