Abstract The principal goal of this study is to evaluate the interaction of Fe3O4@CaAl-LDH@L-Dopa and Fe3O4@CaAl-LDH nanoparticles with calf thymus DNA. The magnetic nanoparticles were previously prepared by a chemical co-precipitation method, and the surface of the Fe3O4 nanoparticles was coated with CaAl layered double hydroxides. The antiparkinsonian drug “L-Dopa” was carried by this core–shell nanostructure to achieve the drug delivery system with suitable properties for biological applications. Also, the interaction of Fe3O4@CaAl-LDH@L-Dopa and Fe3O4@CaAl-LDH nanoparticles with CT-DNA was studied using, UV–Visible spectroscopy, viscosity, circular dichroism (CD), and fluorescence spectroscopy techniques. The results of investigations demonstrated that Fe3O4@CaAl-LDH@L-Dopa and Fe3O4@CaAl-LDH nanoparticles have interacted via minor groove binding and intercalated to CT-DNA, respectively.

中文翻译：

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Fe3O4@CaAl-LDH@L-Dopa与小牛胸腺DNA的沟结合相互作用的体外光谱研究

摘要 本研究的主要目的是评估 Fe3O4@CaAl-LDH@L-Dopa 和 Fe3O4@CaAl-LDH 纳米颗粒与小牛胸腺 DNA 的相互作用。磁性纳米粒子预先通过化学共沉淀法制备，Fe3O4纳米粒子表面包覆有CaAl层状双氢氧化物。抗帕金森病药物“左旋多巴”由这种核壳纳米结构承载，以实现具有适合生物应用特性的药物递送系统。此外，还使用紫外-可见光谱、粘度、圆二色性 (CD) 和荧光光谱技术研究了 Fe3O4@CaAl-LDH@L-Dopa 和 Fe3O4@CaAl-LDH 纳米颗粒与 CT-DNA 的相互作用。