Abstract High levels of miR-19 play an important role in malignant diseases of the hematopoietic system. Therefore the treatment with corresponding microRNA antagonists seems to be an interesting therapeutic approach. We found a significant increase of apoptosis in Jurkat cells which were transfected with a miR-19b inhibitor. The rise of apoptosis in transfected human monocuclear cells (MNCs) was significant as well, but the unspecific miRNA control induced apoptosis in MNCs to a similar extend. A closer look at the MNC subpopulations revealed higher specific apoptosis in B cells whereas T cell apoptosis was lower and induced by unspecific miRNA interference.

中文翻译：

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miR-19b 抑制诱导细胞凋亡：它是否显示出治疗白血病的潜力？

摘要 高水平的 miR-19 在造血系统的恶性疾病中起重要作用。因此，用相应的微RNA拮抗剂治疗似乎是一种有趣的治疗方法。我们发现转染了 miR-19b 抑制剂的 Jurkat 细胞的细胞凋亡显着增加。转染的人单核细胞 (MNC) 中细胞凋亡的增加也很显着，但非特异性 miRNA 控制在相似程度上诱导了 MNC 中的细胞凋亡。仔细观察 MNC 亚群，发现 B 细胞特异性凋亡较高，而 T 细胞凋亡较低，并由非特异性 miRNA 干扰诱导。