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A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi.
Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2020-02-24 , DOI: 10.1007/s13659-020-00234-4 Xiu-Rong Wu 1, 2 , Yi Shen 1, 2 , Shu-Jun Cui 1, 2 , Xiao-Lei Luo 1, 2 , Chao-Jiang Xiao 2 , Bei Jiang 1
中文翻译:
来自 Dobinea delavayi 的新型抗疟药 Noreudesmane 倍半萜类化合物。
从Dobinea delavayi的去皮根中分离出一种先前未描述的当归酰化去甲马烷倍半萜类化合物 dobinin O ( 1 ) 以及四种已知的尤地马烷倍半萜类化合物 ( 2 – 5 )。通过广泛的光谱数据分析阐明了它们的结构。此外,化合物1对约氏疟原虫BY265RFP表现出中等的抗疟活性,在30mg/kg/天的剂量下,抑制率为17.8±13.3%。
更新日期:2020-02-24
Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2020-02-24 , DOI: 10.1007/s13659-020-00234-4 Xiu-Rong Wu 1, 2 , Yi Shen 1, 2 , Shu-Jun Cui 1, 2 , Xiao-Lei Luo 1, 2 , Chao-Jiang Xiao 2 , Bei Jiang 1
Affiliation
Abstract
One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2–5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compound 1 exhibited moderate antimalarial activity against Plasmodium yoelii BY265RFP with the inhibition ratio of 17.8 ± 13.3% at the dose of 30 mg/kg/day.Graphic Abstract
中文翻译:
来自 Dobinea delavayi 的新型抗疟药 Noreudesmane 倍半萜类化合物。
抽象的
从Dobinea delavayi的去皮根中分离出一种先前未描述的当归酰化去甲马烷倍半萜类化合物 dobinin O ( 1 ) 以及四种已知的尤地马烷倍半萜类化合物 ( 2 – 5 )。通过广泛的光谱数据分析阐明了它们的结构。此外,化合物1对约氏疟原虫BY265RFP表现出中等的抗疟活性,在30mg/kg/天的剂量下,抑制率为17.8±13.3%。