Immunologic abnormalities of natural killer (NK) cells and T cells play a role in the pathogenesis of systemic lupus erythematosus (SLE). CD161 is expressed on most of the NK cells and on some T cells. The quantities of CD161‐expressing cells and expression levels of CD161 were analyzed in T cells and NK cells from patients with SLE compared with normal controls. The expression of CD161 on NK cells, NKT cells, CD4⁺ T cells, and CD8⁺ T cells in peripheral blood from patients with inactive SLE and active SLE, and from the normal controls group were determined using flow cytometry. The frequency and expression level of CD161 in the lymphocyte subsets and its relationship with the quantity of regulatory T cells, anti‐double stranded DNA antibody, and the titer of antinuclear antibody were evaluated. Both the percentages of the CD161⁺ subpopulation and the mean fluorescence intensities (MFIs) of CD161 in CD8⁺ T cells and NKT cells decreased significantly in SLE patients compared with normal controls (P  < .001). The CD161 expression in CD8⁺ T cells and NKT cells also decreased in the anti‐dsDNA (+) group (P  < .05). The counts of Treg cells were lower in SLE patients and were weakly correlated with the percentage of the CD161 subpopulation (r  = 0.229, P  = .016) and the MFIs of CD161 expression in CD8⁺ T cells (r  = .232, P  = .014). The frequencies and levels of CD161 expression on CD8⁺ T cells and NKT cells were reduced in SLE patients, suggesting that an abnormality of these cells was related to the pathogenesis of SLE.

中文翻译：

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系统性红斑狼疮患者外周血CD8 + T细胞和自然杀伤性T细胞中CD161频率和表达水平的变化。

天然杀伤（NK）细胞和T细胞的免疫异常在系统性红斑狼疮（SLE）的发病机理中起作用。CD161在大多数NK细胞和某些T细胞上表达。与正常对照相比，分析了SLE患者的T细胞和NK细胞中表达CD161的细胞数量和CD161的表达水平。CD161在NK细胞，NKT细胞，CD4 ⁺ T细胞和CD8 ^{+上的表达}使用流式细胞仪检测非活动性SLE和活动性SLE患者以及正常对照组的外周血T细胞。评估淋巴细胞亚群中CD161的频率和表达水平，以及与调节性T细胞，抗双链DNA抗体和抗核抗体滴度的关系。与正常对照组相比，SLE患者的CD8 ⁺ T细胞和NKT细胞中CD161 ⁺亚群的百分比和CD161的平均荧光强度（MFI）均显着降低（P  <.001）。抗dsDNA（+）组的CD8 ⁺ T细胞和NKT细胞中的CD161表达也降低了（P <.05）。Treg细胞的计数在SLE患者均较低，并与CD161亚群的百分比均弱相关（[R  = 0.229，P  = 0.016）和CD161表达的CD8的小额金融机构⁺ T细胞（[R  = 0.232，P  = .014）。SLE患者CD8 ⁺ T细胞和NKT细胞上CD161表达的频率和水平降低，表明这些细胞的异常与SLE的发病机制有关。