Aim and Objective: Parkinson’s disease (PD) is the second most common neurodegenerative disease. It is a multifactorial disorder (caused by aging, environmental, and genetic factors). Metabolomics can help explore the biomarker profiles for aging. Recent studies showed an association between the glutathione S-transferases (GSTs) polymorphisms and PD risk. The purpose of this study was to evaluate the association of this genetic polymorphism and the metabolomic profile in PD Tunisian patients, in order to identify effective biomarkers in the genetic differentiation.

Materials and Methods: In this study, the metabolomic profile changes related to GSTs polymorphism were searched in 54 Tunisian PD patients treated with L-dopa, using a gas chromatography-mass spectrometry (GC-MS) technique.

Results: The study results showed that mannose, methyl stearate, and three other unknown metabolites, increased in patients with GSTM1 positive genotype, while glycolic acid, porphine, monomethyl phosphate, fumaric acid, and three other unknown metabolites decreased in patients with GSTM1 positive genotype. Subsequently, the levels of glycolic acid, erythronic acid, lactic acid, citric acid, fructose, stearic acid, 2-amino-2-methyl-1,3-propanediol and three other unknown metabolites increased in patients with GSTM1 positive genotype, while the levels of proline, valine and two unknown metabolites decreased with GSTT1 positive genotype.

Conclusion: All these altered metabolites are related to energy metabolism and it can be concluded that GSTs polymorphism based the shifting in energy metabolism and led to oxidative stress.

目的和目的：帕金森氏病（PD）是第二常见的神经退行性疾病。它是一种多因素疾病（由衰老，环境和遗传因素引起）。代谢组学可以帮助探索生物标志物的衰老。最近的研究表明谷胱甘肽S-转移酶（GSTs）多态性与PD风险之间存在关联。这项研究的目的是评估这种遗传多态性与突尼斯PD患者的代谢组学特征之间的关系，以鉴定遗传分化中的有效生物标志物。

材料和方法：本研究使用气相色谱-质谱（GC-MS）技术，对54名接受L-多巴治疗的突尼斯PD患者的GST多态性相关的代谢组学谱变化进行了研究。

结果：研究结果表明，GSTM1阳性基因型患者中的甘露糖，硬脂酸甲酯和其他三种未知代谢物增加，而GSTM1阳性基因型患者中的乙醇酸，吗啡，磷酸一甲酯，富马酸和其他三种未知代谢物减少。 。随后，GSTM1阳性基因型患者的乙醇酸，赤藓酸，乳酸，柠檬酸，果糖，硬脂酸，2-氨基-2-甲基-1,3-丙二醇和其他三种未知代谢物的水平升高，而GSTT1阳性基因型降低了脯氨酸，缬氨酸和两种未知代谢产物的水平。

结论：所有这些改变的代谢物都与能量代谢有关，可以得出结论，GSTs多态性是基于能量代谢的改变并导致氧化应激。