Background: Avicennia alba Blume, is a well-known mangrove plant used in traditional medicinal practices for several human ailments.

Objective: The study aimed at the evaluation of antidiabetic, antioxidant, anti-inflammatory and cytotoxic activities of A. alba ethanolic leaf (AAL) and bark (AAB) extract along with phytochemical investigation.

Methods: In vitro antidiabetic study was done by α-amylase, α-glucosidase enzyme inhibition assay; antioxidant study by DPPH, ABTS, superoxide, and metal chelating assays, antiinflammatory study by protein denaturation assay. The cytotoxicity study was done on TC1 murine cell line. Further, GC-MS analysis was carried out for AAL extracts.

Results: AAL exhibited better antidiabetic activities with IC50 values of 1.18 and 0.87 mg/ml against α-amylase and α-glucosidase enzymes respectively. The AAL exhibited better ABTS, superoxide scavenging and metal chelating potential with IC50 values of 0.095, 0.127 and 0.444 mg/ml. However, AAB showed higher DPPH scavenging potential with IC50 value of 0.163 mg/ml. The AAL also exhibited higher protein denaturation potential with IC50 value of 0.370 mg/ml. The bark extract exhibited better cytotoxic activity as compared to leaf extracts on the TC1 murine cell line. The phytochemical study revealed higher total phenol (25.64 mg GAE/g), flavonoid (205.09 mg QE/g), and tannin content (251.17 mg GAE/g) in AAL. The GC-MS analysis revealed the presence of several compounds in AAL extract.

Conclusion: The result of the present study highlights the antidiabetic, antioxidant and cytotoxic activities of mangrove plant Avicennia alba.

背景：Avicennia alba Blume是一种著名的红树林植物，用于传统医学实践中，可治疗多种人类疾病。

目的：本研究旨在评估白曲木乙醇叶（AAL）和树皮（AAB）提取物的抗糖尿病，抗氧化，抗炎和细胞毒性活性，并进行植物化学研究。

方法：采用α-淀粉酶，α-葡萄糖苷酶抑制试验进行体外抗糖尿病研究。通过DPPH，ABTS，超氧化物和金属螯合分析进行抗氧化剂研究，通过蛋白质变性分析进行抗炎研究。细胞毒性研究是在TC1鼠细胞系上进行的。另外，对AAL提取物进行了GC-MS分析。

结果：AAL表现出更好的抗糖尿病活性，对α-淀粉酶和α-葡萄糖苷酶的IC50值分别为1.18和0.87 mg / ml。AAL表现出更好的ABTS，超氧化物清除和金属螯合电位，IC50值为0.095、0.127和0.444 mg / ml。但是，AAB表现出更高的清除DPPH的潜力，IC50值为0.163 mg / ml。AAL还表现出更高的蛋白质变性潜力，IC50值为0.370 mg / ml。与在TC1鼠细胞系上的叶提取物相比，树皮提取物表现出更好的细胞毒性活性。植物化学研究显示，AAL中的总酚含量较高（25.64 mg GAE / g），类黄酮（205.09 mg QE / g）和单宁含量（251.17 mg GAE / g）。GC-MS分析表明AAL提取物中存在几种化合物。

结论：本研究的结果突出了红树林植物白盲草的抗糖尿病，抗氧化和细胞毒性活性。