Subjectives: 

Lewy body dementia (LBD) is the second most common type of neurodegenerative dementia after Alzheimer disease (AD). It is characterized by the accumulation of Lewy bodies and Lewy neurites which are composed of aggregated phosphorylated alpha-synuclein, which is a presynaptic neuronal protein genetically and neuropathologically linked to Parkinson disease and to LBD. Alpha-synuclein is thought to contribute to LBD pathogenesis and to linked to disruption of cellular homeostasis and neuronal death, through effects on various intracellular targets, including synaptic function.

Methods: 

In the present study, we did a meta-analysis on the reliability of alpha-synuclein levels in the cerebrospinal fluid (CSF) for the discrimination between LBD and other neurodegenerative disorders including AD, Parkinson disease (PD) dementia, progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and frontotemporal dementia (FTD).

Results: 

CSF alpha-synuclein levels were significantly different in LBD compared with AD, but no statistical difference was found between LBD, and dementia in PD, MSA, PSP, and FTD.

Conclusion: 

Alpha-synuclein levels in the CSF can be used for the discrimination between LBD and AD, but not LBD and other neurodegenerative disorders such as dementia in PD, MSA, FTD, and PSP.

中文翻译：

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路易体痴呆和其他神经退行性疾病的鉴别诊断中的α-突触核蛋白水平：荟萃分析。

主观： 

路易体痴呆症（LBD）是仅次于阿尔茨海默病（AD）的第二大神经退行性痴呆类型。它的特征在于路易体和路易神经突的积累是由聚集的磷酸化α-突触核蛋白组成的，磷酸化的α-突触核蛋白是与帕金森氏病和LBD遗传和神经病理相关的突触前神经元蛋白。人们认为，α-突触核蛋白通过影响各种细胞内靶标（包括突触功能）来促进LBD发病机理，并与破坏细胞稳态和神经元死亡有关。

方法： 

在本研究中，我们对脑脊液（CSF）中α-突触核蛋白水平在区分LBD和其他神经退行性疾病（包括AD，帕金森病（PD）痴呆，进行性核上性麻痹（PSP））中的可靠性进行了荟萃分析。 ），多系统萎缩（MSA）和额颞叶痴呆（FTD）。

结果： 

与AD相比，LBD中的CSFα-突触核蛋白水平显着不同，但在PD，MSA，PSP和FTD中，LBD与痴呆之间无统计学差异。

结论： 

CSF中的α-突触核蛋白水平可用于区分LBD和AD，但不能区分LBD和其他神经退行性疾病，例如PD，MSA，FTD和PSP中的痴呆。