Objective. Repair and regeneration of peripheral nerve defect by engineered conduits have greatly advanced in the past decades while still facing great challenges. Approach. In this work, we fabricated a new highly oriented poly(L-lactic acid) (PLLA)/soy protein isolate (SPI) nanofibrous conduit (HO-PSNC) for nerve regeneration. Main results. Firstly, we observed that SPI could efficiently modify PLLA for the electrospinning of PLLA/SPI nanofibers with enhanced physical and biological properties. Incorporation of SPI decreased the fiber diameter and ductility of PLLA/SPI nanofibrous films (PSNFs), improved the tensile strength and surface wettability of PSNFs and increased the in vivo degradability of the PSNFs. When the hybrid ratio of SPI was 20 and 40%, PSNFs could efficiently promote neural cell extension and differentiation in vitro . Based on these data, 20% SPI (PSNF-20) was chosen for further investigation. Next, PSNF-20 with different ...

中文翻译：

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对齐的大豆分离蛋白修饰的聚（L-乳酸）纳米纤维导管增强了周围神经的再生。

目的。在过去的几十年中，通过工程导管修复和再生周围神经缺损已经取得了很大进展，同时仍然面临着巨大挑战。方法。在这项工作中，我们制造了一种新的高度定向的聚L-乳酸（PLLA）/大豆分离蛋白（SPI）纳米纤维导管（HO-PSNC），用于神经再生。主要结果。首先，我们观察到SPI可以有效地修饰PLLA，从而对PLLA / SPI纳米纤维进行静电纺丝，具有增强的物理和生物学特性。掺入SPI可以降低PLLA / SPI纳米纤维膜（PSNFs）的纤维直径和延展性，提高PSNFs的拉伸强度和表面润湿性，并提高PSNFs的体内降解性。当SPI的混合比为20％和40％时，PSNFs可以有效促进体外神经细胞的延伸和分化。基于这些数据，选择了20％SPI（PSNF-20）进行进一步研究。接下来，PSNF-20具有不同的...