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Cellulose acetate-gelatin coated boron-bioactive glass biocomposite scaffolds for bone tissue engineering.
Biomedical Materials ( IF 3.9 ) Pub Date : 2020-09-23 , DOI: 10.1088/1748-605x/ab8d47
Reza Moonesi Rad 1 , Ammar Z Alshemary 2 , Zafer Evis 3 , Dilek Keskin 1, 3, 4 , Ayşen Tezcaner 1, 3, 4
Affiliation  

In this study, we aimed to prepare and characterize porous scaffolds composed of pure and boron oxide (B 2 O 3 )-doped bioactive glass (BG) that were infiltrated by cellulose acetate-gelatin (CA-GE) polymer solution for bone tissue engineering applications. Composite scaffolds were cross-linked with glutaraldehyde after polymer coating to protect the structural integrity of the polymeric-coated scaffolds. The impact of B 2 O 3 incorporation into BG-polymer porous scaffolds on the cross-sectional morphology, porosity, mechanical properties, degradation and bioactivity of the scaffolds was investigated. Human dental pulp stem cells (hDPSCs) were enzymatically isolated and used for cell culture studies. According to scanning electron microscope analysis, the porous structure of the scaffolds was preserved after polymer coating. After polymer infiltration, the porosity of the scaffolds decreased from 64.2% to 59.35% for pure BG scaffolds and from...

中文翻译:

用于骨组织工程的醋酸纤维素-明胶涂层硼生物活性玻璃生物复合材料支架。

在本研究中,我们旨在制备和表征由纯氧化硼 (B 2 O 3 ) 掺杂的生物活性玻璃 (BG) 组成的多孔支架,该玻璃被醋酸纤维素 - 明胶 (CA-GE) 聚合物溶液浸润,用于骨组织工程应用程序。复合支架在聚合物涂层后与戊二醛交联,以保护聚合物涂层支架的结构完整性。研究了B 2 O 3 掺入BG-聚合物多孔支架对支架的横截面形态、孔隙率、机械性能、降解和生物活性的影响。人牙髓干细胞 (hDPSCs) 被酶法分离并用于细胞培养研究。根据扫描电镜分析,聚合物涂层后支架的多孔结构得以保留。
更新日期:2020-09-24
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