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Facile synthesis of anisotropic gold nanoparticles and its synergistic effect on breast cancer cell lines.
IET Nanobiotechnology ( IF 2.3 ) Pub Date : 2020-05-01 , DOI: 10.1049/iet-nbt.2019.0279
Mubarak Jannathul Firdhouse 1 , Pottail Lalitha 2
Affiliation  

Gold nanoparticles (AuNPs) possess colourful light-scattering properties due to different composition, size and shape. Their unique physical, optical and chemical properties coupled with advantages, have increased the scope of anisotropic AuNPs in various fields. This study reports a green methodology developed for the synthesis of anisotropic AuNPs. The aqueous extracts of Alternanthera sessilis (PGK), Portulaca oleracea (PAK) and Sterculia foetida (SF) with gold ions produced violet, purple and pink coloured AuNPs, respectively, under sonication and room temperature methods revealing the formation of different shapes of AuNPs. The results of TEM analysis of AuNPs confirmed the formation of triangular plate AuNPs of the size 35 nm for PAK extract. Spherical-shaped AuNPs (10-20 nm) were obtained using an extract of PGK. SF extract produced rod, hexagon, pentagon-shaped AuNPs and nanorice gold particles. The cell viability studies of the PGK, PAK and SF-mediated AuNPs on MCF-7 cell lines by MTT assay revealed the cytotoxic activity of AuNPs to depend on the size, shape and the nature of capping agents. The synthesised AuNPs significantly inhibited the growth of cancer cells (MCF-7) in a concentration-dependent manner. The size and shape of these anisotropic AuNPs also reveal its potency to be used as sensors, catalysis, photothermal and therapeutic agents.

中文翻译:

各向异性金纳米粒子的简便合成及其对乳腺癌细胞系的协同作用。

由于不同的成分、大小和形状,金纳米粒子 (AuNPs) 具有彩色的光散射特性。其独特的物理、光学和化学性质加上优势,增加了各向异性金纳米粒子在各个领域的应用范围。本研究报告了一种为合成各向异性金纳米粒子而开发的绿色方法。在超声和室温方法下,用金离子提取的交替参 (PGK)、马齿苋 (PAK) 和胖大海 (SF) 的水提取物分别产生了紫色、紫色和粉红色的 AuNPs,揭示了不同形状的 AuNPs 的形成。AuNPs 的 TEM 分析结果证实了 PAK 提取物形成了大小为 35 nm 的三角形板 AuNPs。使用 PGK 的提取物获得球形金纳米粒子 (10-20 nm)。SF提取物生产棒,六边形、五边形金纳米粒子和纳米金颗粒。通过 MTT 法对 PGK、PAK 和 SF 介导的 AuNPs 在 MCF-7 细胞系上的细胞活力研究表明,AuNPs 的细胞毒活性取决于封端剂的大小、形状和性质。合成的 AuNPs 以浓度依赖性方式显着抑制癌细胞 (MCF-7) 的生长。这些各向异性金纳米粒子的大小和形状也揭示了其用作传感器、催化、光热和治疗剂的潜力。合成的 AuNPs 以浓度依赖性方式显着抑制癌细胞 (MCF-7) 的生长。这些各向异性金纳米粒子的大小和形状也揭示了其用作传感器、催化、光热和治疗剂的潜力。合成的 AuNPs 以浓度依赖性方式显着抑制癌细胞 (MCF-7) 的生长。这些各向异性金纳米粒子的大小和形状也揭示了其用作传感器、催化、光热和治疗剂的潜力。
更新日期:2020-05-01
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