Deregulation of microRNAs expression is symptomatic of cancer disease and occurs before the awareness of cancer signs. Early detection of cancer disease can improve or drop the disease entirely. DNA computing is an emerging field of detecting microRNAs based on toehold-mediated strand displacement reactions, which is a more efficient method than the commonly used method like real-time PCR. Accuracy and cost of diagnostic applications are essential criteria that are achieved by using the DNA logic gates based on the DNA computing method. In this study, the authors proposed the multi-input liver cancer biosensor with the RNA secondary structure motifs as the computational module and two approaches are suggested.

中文翻译：

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用于分析 microRNA 癌症生物标志物的 RNA 二级结构逻辑门。


microRNA 表达失调是癌症疾病的症状，并且发生在意识到癌症迹象之前。癌症疾病的早期发现可以改善或完全消除该疾病。 DNA 计算是基于立足点介导的链置换反应检测 microRNA 的新兴领域，这是一种比实时 PCR 等常用方法更有效的方法。诊断应用的准确性和成本是使用基于DNA计算方法的DNA逻辑门实现的基本标准。在这项研究中，作者提出了以 RNA 二级结构基序作为计算模块的多输入肝癌生物传感器，并提出了两种方法。