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Clinical utility of cardiac troponin measurement in COVID-19 infection.
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine ( IF 2.1 ) Pub Date : 2020-04-27 , DOI: 10.1177/0004563220921888
David C Gaze 1, 2
Affiliation  

The novel coronavirus SARS-CoV-2 causes the disease COVID-19, a severe acute respiratory syndrome. COVID-19 is now a global pandemic and public health emergency due to rapid human-to-human transmission. The impact is far-reaching, with enforced social distancing and isolation, detrimental effects on individual physical activity and mental wellbeing, education in the young and economic impact to business. Whilst most COVID-19 patients demonstrate mild-to-moderate symptoms, those with severe disease progression are at a higher risk of mortality. As more is learnt about this novel disease, it is becoming evident that comorbid cardiovascular disease is associated with a greater severity and increased mortality. Many patients positive for COVID-19 demonstrate increased concentrations of cardiac troponin, creating confusion in clinical interpretation. While myocardial infarction is associated with acute infectious respiratory disease, the majority of COVID-19 patients demonstrate stable cTn rather than the dynamically changing values indicative of an acute coronary syndrome. Although full understanding of the mechanism of cTn release in COVID-19 is currently lacking, this mini-review assesses the limited published literature with a view to offering insight to pathophysiological mechanisms and reported treatment regimens.



中文翻译:


心肌肌钙蛋白测量在 COVID-19 感染中的临床应用。



新型冠状病毒 SARS-CoV-2 会导致新冠肺炎 (COVID-19),这是一种严重急性呼吸系统综合症。由于人与人之间的快速传播,COVID-19 现在已成为全球流行病和突发公共卫生事件。影响是深远的,强制的社会距离和隔离,对个人身体活动和心理健康、年轻人的教育以及对商业的经济影响产生有害影响。虽然大多数 COVID-19 患者表现出轻度至中度症状,但病情严重进展的患者死亡风险更高。随着对这种新疾病的了解越来越多,越来越明显的是,合并心血管疾病与更严重的严重性和更高的死亡率相关。许多 COVID-19 呈阳性的患者表现出心肌肌钙蛋白浓度升高,导致临床解释混乱。虽然心肌梗死与急性传染性呼吸道疾病相关,但大多数 COVID-19 患者表现出稳定的 cTn,而不是指示急性冠状动脉综合征的动态变化值。尽管目前缺乏对 COVID-19 中 cTn 释放机制的充分了解,但这篇小型综述评估了有限的已发表文献,以期深入了解病理生理机制和报道的治疗方案。

更新日期:2020-06-30
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