Current Protein & Peptide Science ( IF 1.9 ) Pub Date : 2020-05-31 , DOI: 10.2174/1389203721666200426233758 Elsie C Jimenez 1
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All life forms typically possess homochirality, with rare exceptions. In the case of peptides and proteins, only L-amino acids are known to be encoded by genes. Nevertheless, D-amino acids have been identified in a variety of peptides, synthesized by animal cells. They include neuroexcitatory and neuroprotective peptides, cardioexcitatory peptides, hyperglycemic hormones, opioid peptides, antimicrobial peptides, natriuretic and defensin-like peptides, and fibrinopeptides. This article is a review of their occurrence, structure and bioactivity. It further explores the pharmacology and potential medical applications of some of the peptides.
中文翻译：
动物，包括人在内的肽中的D-氨基酸：发生，结构，生物活性和药理学。
除少数例外，所有生命形式通常都具有手性。就肽和蛋白质而言，已知只有L-氨基酸由基因编码。然而，已经在由动物细胞合成的多种肽中鉴定出D-氨基酸。它们包括神经兴奋肽和神经保护肽，心脏兴奋肽，高血糖激素，阿片样肽，抗菌肽，利钠肽和防御素样肽，以及纤维蛋白肽。本文是对它们的发生，结构和生物活性的综述。它进一步探讨了某些肽的药理学和潜在医学应用。
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