Based on the anti-aggregation mechanism of citrate stabilized gold nanoparticle (AuNPs), a new specific and sensitive colorimetric sensor for thiocyanate (SCN⁻) was developed. In this scheme, the AuNPs were aggregated in the presence of the aggregating agent 2-aminopyridine (2-AP) due to electrostatic attraction. The solution color changed from red to blue. When SCN⁻ was present, SCN⁻ formed a sulfur–gold bond with the AuNPs to protect the AuNPs from aggregation. Thiocyanate can be detected by the color change of the solution from blue to red. The results showed that the absorbance ratio A₆₇₅/A₅₂₀ was linear with the concentration of SCN⁻ in the range of 0.4 – 1.2 μmol L⁻¹ by UV-Vis spectroscopy. The limit of detection (LOD) of this assay was 0.37 μmol L⁻¹. The system also had excellent selectivity and anti-interference ability. In addition, this method was successfully used for the detection of SCN⁻ in actual water samples and achieved good results.

基于柠檬酸盐稳定金纳米颗粒（AuNPs）的抗聚集机制，开发了一种新型特异性、灵敏的硫氰酸盐（SCN ^{- ）比色传感器。}在该方案中，AuNPs 在聚集剂 2-氨基吡啶 (2-AP) 存在下由于静电引力而聚集。溶液颜色由红色变为蓝色。当 SCN ^-存在时，SCN ^-与 AuNP 形成硫-金键，以保护 AuNP 免于聚集。硫氰酸盐可以通过溶液的颜色从蓝色到红色的变化来检测。紫外-可见光谱分析结果表明，吸光度比A ₆₇₅ / A _520与SCN ^-浓度在0.4 ~ 1.2 μmol L ^-1范围内呈线性关系。该测定的检测限(LOD)为0.37 μmol L ^-1。该系统还具有优良的选择性和抗干扰能力。此外，该方法还成功用于实际水样中SCN−的检测，取得了良好的^结果。