The benefits of aerobic exercise in persons with Parkinson's disease (PD) have been widely studied. Recent studies support the use of high-intensity aerobic exercise to improve oxidative stress values and functional performance in PD patients. The aim of this study is ascertain whether high-intensity aerobic training with lower extremity cycle ergometers and balance training can improve motor symptoms and quality of life in a PD population of Hoehn and Yahr disability score 1–3. The intervention took place in rehabilitation centers in secondary care. A pilot randomized controlled trial was carried out with 14 outpatients participated in the 8-week study. They were composed of a control group (CG; n = 7) that followed a balance protocol and an experimental group (EG; n = 7) that performed high-intensity (70% heart rate reserve) aerobic workout using a lower extremity cycle ergometer and a balance protocol once a week. The primary outcome measures included the 8-Foot Up-and-Go test, 6-Minute Walk test, 2-Minute Step test, Parkinson's Disease Questionnaire (PDQ39), Movement Disorder Society—Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and Tinetti test. Significant improvements in the PDQ39 (F_1.23 = 3.102; sig = 0.036), the MDS-UPDRS III (F_1.23 = 4.723; sig = 0.033), and MDS-UPDRS Total (F_1.23 = 4.117; sig = 0.047) were observed in the EG as against the CG. After taking into account the number of subjects in each group, the results suggest that the PD population can withstand high-intensity aerobic workouts with a lower extremity cycle ergometer. This exercise is a beneficial therapy for them because it reduces motor symptoms of the disease and furthermore increases and improves patient's quality of life.

中文翻译：

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高强度渐进式循环计划对帕金森病人群生活质量和运动症状的影响：一项试点随机对照试验。

有氧运动对帕金森病 (PD) 患者的益处已得到广泛研究。最近的研究支持使用高强度有氧运动来改善 PD 患者的氧化应激值和功能表现。本研究的目的是确定使用下肢循环测力计和平衡训练的高强度有氧训练是否可以改善 Hoehn 和 Yahr 残疾评分 1-3 的 PD 人群的运动症状和生活质量。干预在二级保健康复中心进行。进行了一项试点随机对照试验，14 名门诊患者参与了为期 8 周的研究。他们由 遵循平衡协议的对照组（CG；n = 7）和实验组（EG；n = 7) 每周一次使用下肢循环测力计和平衡方案进行高强度（70% 心率储备）有氧运动。主要结果测量包括 8 英尺起跳测试、6 分钟步行测试、2 分钟步进测试、帕金森氏病问卷 (PDQ39)、运动障碍协会 - 统一帕金森氏病评定量表 (MDS-UPDRS) 和蒂内蒂测试。PDQ39 ( F _1.23  = 3.102; sig = 0.036)、MDS-UPDRS III ( F _1.23  = 4.723; sig = 0.033) 和 MDS-UPDRS Total ( F _1.23 = 4.117; sig = 0.047) 在 EG 中与 CG 相比。考虑到每组受试者的数量后，结果表明，PD人群可以承受下肢循环测力计的高强度有氧锻炼。这项运动对他们来说是一种有益的疗法，因为它可以减少疾病的运动症状，并进一步增加和改善患者的生活质量。