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Recent breakthroughs in antimicrobial resistance induced quorum sensing biosynthetic pathway mediated various targets and design of their inhibitors.
Combinatorial Chemistry & High Throughput Screening ( IF 1.6 ) Pub Date : 2020-04-25 , DOI: 10.2174/1386207323666200425205808 Mohit Kumar 1 , Mridula Saxena 2 , Anil K Saxena 3 , Sisir Nandi 1
Combinatorial Chemistry & High Throughput Screening ( IF 1.6 ) Pub Date : 2020-04-25 , DOI: 10.2174/1386207323666200425205808 Mohit Kumar 1 , Mridula Saxena 2 , Anil K Saxena 3 , Sisir Nandi 1
Affiliation
OBJECTIVE
The world is under the grasp of dangerous post-antibiotics and antimicrobials attack where common infections may become untreatable leading to premature deaths due to antimicrobial resistance (AMR). While an estimated 7,00,000 people die annually due to AMR which is a public health threat to all communities in different parts of the world regardless of their economic status. However, this threat is enough in low- and middle-income countries having lack of sanitation and health infrastructure. 68th World Health Assembly endorsed the Global Action Plan on antimicrobial resistance. Consequently, many countries started drafting and committing to National Action Plans against AMR. As strong as National Action Plans are in terms of prescribing rational use of antimicrobials, infection control practices, and related public health measures, without strong health systems, these measures will have a limited impact on AMR in developing countries.
METHODS
The major reason for AMR is due to microbial quorum sensing (QS) that may sturdy the microbial community to generate inter-communication and virulence effects via quorum sensing mechanisms. Global stewardship to combat antimicrobial resistance is to develop anti-quorum sensing compounds that can inhibit the biosynthetic pathway mediated different quorum sensing targets.
RESULTS
It may pave an effective attempt to minimize microbial quorum sensing mediated antimicrobial resistance. The present review describes QS mediated various potential target enzymes, its connection to AMR, and to find out the corresponding QS biosynthetic target inhibitors.
CONCLUSION
These potential inhibitors can be derivatized to design and develop the next-generation antimicrobial agents.
更新日期：2020-04-25
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