A number of clinical studies have revealed that there is an association between major depression (MD) and gastroesophageal reflux disease (GERD). Both the diseases are shown to affect a large proportion of the global population. More advanced studies for understanding the comorbidity mechanism of these two diseases can shed light on developing new therapies of both diseases. To the best of our knowledge, there has not been any research work in the literature investigating the relationship between MD and GERD using their miRNA biomarkers. We adopt a phylogenetic analysis to analyze their miRNA biomarkers. From our analyzed results, the association between these two diseases can be explored through miRNA phylogeny. In addition to evidence from the phylogenetic analysis, we also demonstrate epidemiological evidence for the relationship between MD and GERD based on Taiwan biobank data.

许多临床研究表明，重度抑郁症（MD）与胃食管反流病（GERD）之间存在关联。两种疾病均显示影响很大一部分全球人口。了解这两种疾病合并症机制的更高级研究可以为开发这两种疾病的新疗法提供启示。据我们所知，文献中还没有任何研究使用其miRNA生物标记物研究MD和GERD之间的关系。我们采用系统发育分析来分析其miRNA生物标记。根据我们的分析结果，可以通过miRNA系统发育探索这两种疾病之间的关联。除了系统发育分析的证据外，