The dynamic nature of chromosome organization plays a central role in the regulation of many crucial processes, such as DNA transcription and replication. However, the molecular bases of the link between genomic function, structure and dynamics remain elusive. In this review, we focus on how biophysical modelling can be instrumentally used to rationalize experimental studies of chromosome dynamics, and to probe the impact of putative mechanisms on genome folding kinetics during interphase. We introduce the general connection between chromatin internal organization and dynamics, and outline the potential effects of passive interactions mediated by architectural proteins and of active, energy-dependent processes on chromatin motion. Finally, we discuss current ambiguities emerging from in vivo observations, in particular related to ATP depletion and transcriptional activation, and highlight future perspectives.

中文翻译：

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间期的染色体动力学：生物物理学的观点。

染色体组织的动态性质在许多关键过程（例如DNA转录和复制）的调节中起着核心作用。但是，基因组功能，结构和动力学之间联系的分子基础仍然难以捉摸。在这篇综述中，我们关注于如何利用生物物理模型来合理化染色体动力学的实验研究，并探究推定的机制对相间基因组折叠动力学的影响。我们介绍了染色质内部组织与动力学之间的一般联系，并概述了建筑蛋白介导的被动相互作用以及染色质运动对能量依赖的主动过程的潜在影响。最后，我们讨论了体内观察中出现的当前歧义，