Physical activity impacts brain functions, but the direct mechanisms of this effect are not fully recognized or understood. Among multidimensional changes induced by physical activity, brain fatty acids (FA) appear to play an important role; however, the knowledge in this area is particularly scarce. Here we performed global metabolomics profiling of the hippocampus and the frontal cortex (FC) in a model of voluntary running in mice. Examined brain structures responded differentially to physical activity. Specifically, the markers of the tricarboxylic acid (TCA) cycle were downregulated in the FC, whereas glycolysis was enhanced in the hippocampus. Physical activity stimulated production of myristic, palmitic and stearic FA; i.e., the primary end products of de novo lipogenesis in the brain, which was accompanied by increased expression of hippocampal fatty acid synthase (FASN), suggesting stimulation of lipid synthesis. The changes in the brain fatty acid profile were associated with reduced anxiety level in the running mice. Overall, the study examines exercise-related metabolic changes in the brain and links them to behavioral outcomes.

中文翻译：

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进行体育锻炼可以减少焦虑并调节大脑脂肪酸的合成。

体力活动会影响大脑功能，但这种作用的直接机制尚未得到充分认识或理解。在体育活动引起的多维变化中，脑脂肪酸（FA）似乎起着重要的作用。但是，这方面的知识特别匮乏。在这里，我们在小鼠自愿奔跑的模型中对海马和额叶皮层（FC）进行了整体代谢组学分析。检查的大脑结构对身体活动的反应不同。具体来说，三羧酸（TCA）循环的标志物在FC中被下调，而海马中的糖酵解作用增强。体育锻炼刺激了肉豆蔻，棕榈酸和硬脂酸FA的产生；即大脑中从头脂肪形成的主要终产物，伴有海马脂肪酸合酶（FASN）表达增加，提示脂质合成受到刺激。脑脂肪酸谱的变化与正在奔跑的小鼠的焦虑水平降低有关。总的来说，这项研究检查了与运动有关的大脑代谢变化，并将其与行为结果联系起来。