Aim of the study: Following exposure to toxic chemicals, skin uptake is a potential route of intoxication. Therefore, efficient methods for rapid skin decontamination to mitigate systemic effects are of utmost importance. In operational guidelines, skin decontamination is recommended to be performed by dry absorption and washing with water or soapy water. In the present study, evaluation of decontamination efficacy using water or soapy water was performed for five chemicals, three toxic industrial chemicals and two simulants for chemical warfare agents.Materials and methods: Decontamination was initiated at time points 5, 15, 45 and 120 min after exposure in order to evaluate the time window for efficient decontamination. Experiments were conducted utilizing an in vitro skin penetration model to allow exposure of toxic chemicals on human skin. Results: For all test substances, it was clearly demonstrated that decontamination had greater efficacy when initiated at the earliest time-point while decontamination after 120 min was less efficient. Adding soap to the water showed no significant improvement for any of the tested substances.Conclusion: These results are of reledvance for the development of efficient operational decontamination procedures.

中文翻译：

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在人体皮肤上接触有毒化学物质后，用肥皂水和水洗去污的功效。

研究目的：接触有毒化学物质后，皮肤摄取是潜在的中毒途径。因此，快速皮肤去污以减轻全身作用的有效方法至关重要。在操作指南中，建议通过干吸收并用水或肥皂水洗涤进行皮肤净化。在本研究中，对5种化学药品，3种有毒工业化学药品和2种用于化学战剂的模拟物进行了水或肥皂水的去污效果评估。材料和方法：在5、15、45和120分钟的时间点开始进行去污暴露后评估有效净化时间窗。利用体外皮肤渗透模型进行实验，以使有毒化学物质暴露在人的皮肤上。结果：对于所有测试物质，都清楚地表明，尽早开始净化工作具有更高的功效，而120分钟后的净化效率则更低。对于任何测试物质，向水中添加肥皂均无明显改善。结论：这些结果与开发有效的操作性去污程序有关。