The period from the 1990s to the 2010s has witnessed a burgeoning sea change in the practice of surgical neuropathology due to the incorporation of genomic data into the assessment of a range of central nervous system (CNS) neoplasms. This change has since matured into the adoption of genomic information into the definition of several World Health Organization (WHO)-established diagnostic entities. The data needed to accomplish the modern diagnosis of CNS neoplasia includes DNA copy number aberrations that may be assessed through a variety of mechanisms. Through a review of the relevant literature and professional practice guidelines, here we provide a condensed and scored overview of the most critical DNA copy number aberrations to assess for a selection of primary CNS neoplasms.

从1990年代到2010年代，由于将基因组数据纳入了一系列中枢神经系统（CNS）肿瘤的评估中，外科神经病理学实践发生了巨大的变化。此后，这种变化已经成熟，将基因组信息纳入了世界卫生组织（WHO）建立的几个诊断实体的定义。完成CNS瘤形成的现代诊断所需的数据包括DNA拷贝数异常，可以通过多种机制进行评估。通过查阅相关文献和专业实践准则，在这里我们提供了最关键的DNA拷贝数畸变的简明和评分总览，以评估对原发性CNS肿瘤的选择。