Sex differences in certain types of pain sensitivity and emotional responses have been previously reported. Synaptic plasticity is a key cellular mechanism for pain perception and emotional regulation, including long-term potentiation (LTP) and long-term depression (LTD). However, it is unclear whether there is a sex difference at synaptic level. Recent studies indicate that excitatory transmission and plasticity in the anterior cingulate cortex (ACC) are critical in chronic pain and pain related emotional responses. In the present study, we used 64-channel multielectrode (MED64) system to record synaptic plasticity in the ACC of male and female adult mice. We found that there was no significant difference in theta-burst stimulation (TBS)-induced LTP between female and male mice. Furthermore, the recruitment of inactive channels was also not different. For LTD, we found that LTD was greater in slices of ACC in male mice than female mice. Our results demonstrate that LTP in the ACC does not show any sex-related difference.

中文翻译：

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成年小鼠前扣带回皮层突触可塑性中的性别差异。

先前已经报道了某些类型的疼痛敏感性和情绪反应中的性别差异。突触可塑性是疼痛感知和情绪调节的关键细胞机制，包括长期增强（LTP）和长期抑郁（LTD）。但是，尚不清楚突触水平上是否存在性别差异。最近的研究表明，前扣带回皮层（ACC）中的兴奋性传递和可塑性对于慢性疼痛和与疼痛相关的情绪反应至关重要。在本研究中，我们使用64通道多电极（MED64）系统记录雄性和雌性成年小鼠ACC中的突触可塑性。我们发现，雌雄小鼠之间的Theta-burst刺激（TBS）诱导的LTP没有显着差异。此外，无效渠道的招聘也没有不同。对于LTD，我们发现，雄性小鼠ACC切片中的LTD大于雌性小鼠。我们的结果表明，ACC中的LTP没有显示任何与性别相关的差异。