BACKGROUND Our previous study found that spray-dried glutinous rice starch (sGRS) is larger in size, rounder in shape and better in flowability than native GRS. It has the potential to be used for direct compression hydrophilic matrix (HM) tablets. OBJECTIVE This study aimed to investigate the factors that affect the propranolol release from directly compressed sGRS HM tablets. METHODS The effects of the amount of sGRS, the compaction pressure and the amount of magnesium stearate on the drug release rate from sGRS directly compressed HM were investigated. In vitro drug releases were performed. The dilution potential of sGRS was investigated. RESULTS The higher the sGRS content, the slower the release rate of propranolol. The compaction pressure and the amount of magnesium stearate did not significantly affect the release rate of the drug. The sGRS showed plastic deformation under compaction with a dilution potential of 46%. CONCLUSIONS sGRS can be used as a direct compression HM. The amount of sGRS significantly affected the release rate of the drug from the matrix.

中文翻译：

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使用喷雾干燥的糯米淀粉作为直接压片亲水性基质片剂的评估。

背景技术我们先前的研究发现，与天然GRS相比，喷雾干燥的糯米淀粉（sGRS）尺寸更大，形状更圆且流动性更好。它具有用于直接压片亲水性基质（HM）片剂的潜力。目的本研究旨在探讨影响直接压制的sGRS HM片剂中普萘洛尔释放的因素。方法研究了sGRS的量，压实压力和硬脂酸镁的量对sGRS直接压制HM药物释放速率的影响。进行体外药物释放。研究了sGRS的稀释潜力。结果sGRS含量越高，普萘洛尔的释放速度越慢。压实压力和硬脂酸镁的量没有显着影响药物的释放速率。sGRS在压实下表现出塑性变形，稀释潜力为46％。结论sGRS可用作直接压缩HM。sGRS的量显着影响药物从基质的释放速率。