The specific features of interactions between megakaryocytic and granulocytic hematopoiesis lineages and myelofibrosis were studied in patients with active phase (before treatment) of chronic myeloid leukemia, chronic lymphocytic leukemia, and multiple myeloma. In patients with chronic myeloid leukemia, a direct correlation was found between the severity of both early and advanced myelofibrosis and the number of megakaryocytes in the bone marrow irrespectively of the type of the bone marrow tumor. The parameters of granulocytic hematopoiesis lineage were higher in myelofibrosis. In patients with chronic lymphocytic leukemia and multiple myeloma, negative correlations between the severity of early and advanced myelofibrosis and the number of megakaryocytes in the bone marrow and platelets in the peripheral blood were found. In chronic lymphocytic leukemia, negative correlations between the severity of early and advanced myelofibrosis and the number of neutrophils in the bone marrow and peripheral blood were detected. In patients with multiple myeloma, negative correlations between the severity of advanced myelofibrosis and number of neutrophils in the bone marrow and peripheral blood were detected.

中文翻译：

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慢性粒细胞白血病、慢性淋巴细胞白血病和多发性骨髓瘤急性期巨核细胞和粒细胞造血谱系与骨髓纤维化相互作用的具体特征

在慢性粒细胞白血病、慢性淋巴细胞白血病和多发性骨髓瘤的活动期（治疗前）患者中研究了巨核细胞和粒细胞造血谱系与骨髓纤维化之间相互作用的具体特征。在慢性粒细胞白血病患者中，发现早期和晚期骨髓纤维化的严重程度与骨髓中巨核细胞的数量之间存在直接相关性，而与骨髓肿瘤的类型无关。粒细胞造血谱系的参数在骨髓纤维化中较高。在慢性淋巴细胞白血病和多发性骨髓瘤患者中，发现早期和晚期骨髓纤维化的严重程度与骨髓中的巨核细胞数量和外周血中的血小板数量呈负相关。在慢性淋巴细胞白血病中，检测到早期和晚期骨髓纤维化的严重程度与骨髓和外周血中的中性粒细胞数量呈负相关。在多发性骨髓瘤患者中，检测到晚期骨髓纤维化的严重程度与骨髓和外周血中的中性粒细胞数量呈负相关。