To evaluate the ground susceptibility of urinary Escherichia coli and Klebsiella pneumoniae to temocillin, the susceptibility of temocillin and comparators against 500 clinical isolates (231 E. coli and 269 K. pneumoniae) was tested. Temocillin was either found as the most active antibiotic (susceptibility rate of 92%) or the fourth most active antibiotic (65%), as per its urinary and systemic breakpoint, respectively. No difference of activity was observed in isolates expressing ESBL/AmpC enzymes. Considering the percentage of isolates expressing beta-lactamases and the need to spare broad-spectrum antibiotics, temocillin seems promising for treating urinary tract infections.

为了评估尿液大肠杆菌和肺炎克雷伯菌对替莫西林的地面敏感性，测试了替莫西林和比较剂对500种临床分离株（231种大肠杆菌和269种肺炎克雷伯菌）的敏感性。根据尿液和全身的断点，发现替莫西林是最活跃的抗生素（敏感性为92％）或第四活跃的抗生素（65％）。在表达ESBL / AmpC酶的分离物中未观察到活性差异。考虑到表达β-内酰胺酶的分离株的百分比以及需要保留广谱抗生素的可能性，替莫西林似乎有望用于治疗尿路感染。