Objective . Transcranial magnetic stimulation (TMS) activates brain structures non-invasively. Computational models can be used to elucidate the activation site; however, the exact activation site is controversial. The aim is to present an imaging technique of the TMS activation cortical site estimation using individualized multi-scale realistic head models based on experimentally-derived TMS fields. Approach. The induced electric field (EF) was computed using subject-specific head models and experimental-specific TMS coil configuration during suprathreshold stimulation for relaxed muscles. The experimentally-derived EFs were used to calculate the activation of pyramidal tract model embedded in the head models to derive the activation site on the cortical surface at the macroscopic level. Main results. The TMS activation site was located at the anterior wall of the central sulcus, which agreed with a concurrent TMS/fMRI study. In contrast, the EF strength wa...

中文翻译：

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使用多尺度逼真的头部模型进行TMS激活位点估计。

目标。经颅磁刺激（TMS）无创地激活大脑结构。计算模型可用于阐明激活位点。但是，确切的激活位点是有争议的。目的是提出一种TMS激活皮质部位估计的成像技术，该技术使用基于实验得出的TMS场的个性化多尺度现实头部模型。方法。在超阈值刺激肌肉放松过程中，使用受试者特定的头部模型和实验特定的TMS线圈配置来计算感应电场（EF）。实验得出的EF用于计算嵌入在头部模型中的锥体束模型的激活，从而在宏观水平上得出皮质表面上的激活位点。主要结果。TMS激活位点位于中央沟的前壁，与同时进行的TMS / fMRI研究一致。相比之下，EF强度却...