Bacteria of the genusGlutamicibacterare considered ubiquitous because they can be found in soil, water and air. They have already been isolated from different habitats, including different types of soil, clinical samples, cheese and plants. Glutamicibacter creatinolyticus is a Gram-positive bacterium important to various biotechnological processes, however, as a pathogen it is associated to urinary tract infections and bacteremia. Recently,Glutamicibacter creatinolyticusLGCM 259 was isolated from a mare, which displayed several diffuse subcutaneous nodules with heavy vascularization. In this study, sequencing, genomic analysis ofG. creatinolyticusLGCM 259 and comparative analyseswere performedamong 4representatives of different members of genusfromdifferent habitats, available in the NCBI database. The LGCM 259 strain's genome carries important factors of bacterial virulence that are essential in cell viability, virulence, and pathogenicity. Genomic islands were predicted for 4 members of genusGlutamicibacter,showing ahigh number of GEIs,which may reflect a high interspecific diversity and a possible adaptive mechanism responsible for the survival of each species in its specific niche. Furthermore,G. creatinolyticusLGCM 259 sharessyntenicregions, albeit with a considerable loss of genes, in relation to the other species. In addition,G. creatinolyticusLGCM 259 presentsresistancegenes to 6 differentclasses ofantibiotics and heavy metals, such as: copper, arsenic, chromium and cobalt-zinc-cadmium.Comparative genomicsanalysescouldcontribute to the identification of mobile genetic elements particular to the speciesG. creatinolyticuscompared to other members of genus. The presence of specific regions inG. creatinolyticuscould be indicative of their rolesin host adaptation, virulence, and the characterization ofastrain that affects animals.

中文翻译：

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母马脓肿产生的解糖谷氨酸杆菌的完整基因组分析和比较基因组学提供了谷氨酸杆菌多样性和适应性的见解。

谷氨酸杆菌属细菌被认为是普遍存在的，因为它们存在于土壤，水和空气中。它们已经从不同的栖息地中分离出来，包括不同类型的土壤，临床样品，奶酪和植物。谷氨酸解氨酶是革兰氏阳性细菌，对各种生物技术过程都很重要，但是，作为一种病原体，它与尿路感染和菌血症有关。最近，从一匹母马中分离出了溶酶性谷氨酸杆菌LGCM 259，它显示出数个弥散性皮下结节，血管沉着。在这项研究中，对G进行测序，基因组分析。在来自不同栖息地的属的不同成员的4个代表中进行了creatinolyticusLGCM 259和比较分析，可在NCBI数据库中获得。LGCM 259株 基因组携带重要的细菌毒力因子，这些因子对细胞生存力，毒力和致病性至关重要。预测谷氨酸杆菌属的4个成员的基因组岛，显示出大量的GEI，这可能反映出高的种间多样性和可能的​​适应机制，其负责每个物种在其特定生态位中的存活。此外，G。creatinolyticusLGCM 259与其他物种相比共有同义区域，尽管基因损失很多。另外，G。creatinolyticusLGCM 259对6种不同类别的抗生素和重金属（例如铜，砷，铬和钴锌镉）表现出抗性基因。比较基因组学分析可有助于鉴定特定于物种G的活动遗传元素。creatinolyticus与其他属相比。G中存在特定区域。creatinolyticus可能表明它们在宿主适应，毒力以及影响动物的毒株特性中的作用。