Coronary artery disease (CAD) is a complex disease with the involvement of the development of atherosclerotic plaque in the wall of the coronary arteries, imposing immense health and economic burdens worldwide [1,2]. It is well recognized that various risk factors, such as dyslipidemia, diabetes, hypertension, physical inactivity, obesity, smoking, and genetics, contribute to the onset and progression of CAD. Despite rapid advances in the understanding of the molecular mechanism of CAD, the number of life-saving drugs is still limited and it is of great importance to develop new strategies for CAD treatment.

中文翻译：

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机械敏感的JCAD：成为动脉粥样硬化的有希望的靶标。

冠状动脉疾病（CAD）是一种复杂的疾病，涉及冠状动脉壁的动脉粥样硬化斑块的发展，给全世界带来了巨大的健康和经济负担[1,2]。众所周知，血脂异常，糖尿病，高血压，缺乏运动，肥胖，吸烟和遗传等各种危险因素均会导致CAD的发作和发展。尽管对CAD的分子机制的理解有了快速的进步，但救生药物的数量仍然有限，因此开发新的CAD治疗策略非常重要。