ABSTRACT

1. Campylobacteriosis is the leading cause of human bacterial gastroenteritis. Broilers are considered the most important source of human Campylobacter infection. In the 2008 European baseline survey Ireland had a 98% prevalence of campylobacter-contaminated broiler carcases.

2. Randomly-selected Campylobacter isolates (296 C. jejuni, 54 C. coli) recovered in 2017 and 2018, from Irish broiler neck skin and caeca were tested for their resistance to tetracycline, erythromycin, gentamicin, ciprofloxacin, nalidixic acid and streptomycin.

3. Overall, 45% of the Campylobacter spp. isolates tested were resistant to at least one antimicrobial. Tetracycline resistance (38%) was most prevalent in C. jejuni, followed by ciprofloxacin and nalidixic acid resistance (29%). In C. coli, resistance to ciprofloxacin and nalidixic acid (26%) was most prevalent followed by resistance to tetracycline (13%). Gentamicin resistance was undetected and resistance to streptomycin was low for C. jejuni (1%) and C. coli (4%). All C. jejuni isolates examined were erythromycin-sensitive, while 9% of C. coli isolates were erythromycin-resistant. Three multidrug-resistant C. coli isolates were recovered.

4. While antibiotic resistance rates were somewhat similar to figures reported nationally over the past 20 years, the prevalence of tetracycline resistance in C. jejuni has increased. The persistence of substantial ciprofloxacin resistance in the Irish broiler population was noteworthy, despite fluoroquinolones having been banned for growth promotion in Europe since 2006.

摘要

1.弯曲杆菌病是人类细菌性肠胃炎的主要原因。肉鸡被认为是人类弯曲杆菌感染的最重要来源。在2008年的欧洲基准调查中，爱尔兰有98％的细菌被弯曲杆菌污染。

2.测试了2017年和2018年从爱尔兰肉鸡颈部皮肤和盲肠中回收的弯曲杆菌分离株（空肠弯曲杆菌296株，大肠杆菌54株）的四环素，红霉素，庆大霉素，环丙沙星，萘啶酸和链霉素的抗药性。

3.总体上，弯曲杆菌属物种的45％。测试的分离株对至少一种抗菌素具有抗性。空肠弯曲菌中四环素耐药性最高（38％），其次是环丙沙星和萘啶酸耐药（29％）。在大肠杆菌中，对环丙沙星和萘啶酸的耐药性最高（26％），其次是对四环素的耐药性（13％）。空肠弯曲杆菌（1％）和大肠杆菌（4％）未检测到庆大霉素的耐药性，对链霉素的耐药性很低。检查的所有空肠弯曲杆菌分离株均对红霉素敏感，而9％的大肠杆菌分离株均对红霉素具有抗性。回收了三个耐多药大肠埃希菌分离株。

4.虽然抗生素耐药率与过去20年全国报告的数字有些相似，但空肠弯曲菌中四环素耐药性的患病率有所增加。值得注意的是，尽管自2006年以来欧洲一直禁止氟喹诺酮类药物用于增长，但爱尔兰肉鸡对环丙沙星的耐药性仍很强。