Objective:It has been hypothesised that neuropsychiatric symptoms, including psychosis, can be the result of a milder brain bioenergetic defect produced by mitochondrial dysfunction; however, mitochondrial dysfunction can be present in other organs or systems. The aim of the study was to investigate whether clinical conditions associated with mitochondrial disorders (CAMDs) were frequently present in schizophrenia.Methods:A previously used questionnaire regarding the CAMDs was administered to patients and controls in a direct interview with a trained psychiatrist. The frequencies of CAMDs in 164 patients with schizophrenia were compared to those in 156 age- and sex-matched controls.Results:Severe fatigue, seizures, constipation and diabetes were significantly more frequent in patients with schizophrenia than in control subjects and apparently not related to pharmacological treatment.Conclusion:The results of the present study suggest that multi-systemic mitochondrial dysfunction may be an underlying mechanism involved in schizophrenia.

中文翻译：

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精神分裂症中通常与线粒体疾病相关的临床病症的高频率

目的：据推测，包括精神病在内的神经精神症状可能是线粒体功能障碍产生的较轻微的脑生物能量缺陷的结果；然而，线粒体功能障碍可能存在于其他器官或系统中。该研究的目的是调查与线粒体疾病 (CAMDs) 相关的临床状况是否经常出现在精神分裂症中。方法：在与训练有素的精神科医生的直接访谈中，对患者和对照组进行了先前使用的有关 CAMDs 的问卷调查。将 164 名精神分裂症患者的 CAMD 频率与 156 名年龄和性别匹配的对照组进行比较。结果：严重疲劳、癫痫发作、