Nanosized magnetite particles (magnetic nanospheres) are a prospective basis for creation of new diagnostic and therapeutic agents. The structure of blood leukocytes and the leukocytic formula are studied in adult rats over a period of 120 days after a single intravenous injection of chitosan-modified nanosized magnetite particles. No effects of chitosan-modified magnetic nanospheres on the structure of rat blood leukocytes are detected. Injection of suspension of chitosan-modified magnetite nanospheres is associated with an increase in the levels of monocytes, segmented and stab neutrophils, and a decrease in lymphocyte counts in the blood of rats. The shifts in the leukogram parameters are transitory, the picture returned to normal by day 40 postinjection.

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壳聚糖修饰磁性纳米球静脉注射大鼠血白细胞

纳米尺寸的磁铁矿颗粒（磁性纳米球）是创造新的诊断和治疗剂的前瞻性基础。在单次静脉注射壳聚糖修饰的纳米磁铁矿颗粒后 120 天内，研究了成年大鼠的血液白细胞结构和白细胞公式。未检测到壳聚糖修饰的磁性纳米球对大鼠血液白细胞结构的影响。注射壳聚糖修饰的磁铁矿纳米球悬浮液与大鼠血液中单核细胞、分段和刺状中性粒细胞水平增加以及淋巴细胞计数减少有关。白细胞图参数的变化是暂时的，在注射后第 40 天图片恢复正常。