Sutureless implantation of the mitral valve bioprosthesis using the valve-in-valve method was performed on a large animal (sheep). According to the results of a two-stage implantation (primary implantation of a xenopericardial 26-mm framed bioprosthesis and reimplantation of the developed 23-mm bioprosthesis), minor changes in quantitative indicators were revealed: an increase in the transprosthetic gradient by 1.3 mm Hg and a decrease in the area of the mitral orifice by 21.6%. Considerable reduction in the intervention time by 18 min was achieved (by 40% in comparison with the primary prosthesis). The absence of adverse events in the animal and complications in the post-operative period, as well as physiological hemodynamic indicators indicate the safety of the developed medical device.

中文翻译：

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瓣中瓣技术二尖瓣无缝线重做初体验：大型动物两阶段植入

在大型动物（绵羊）上使用瓣中瓣法无缝植入二尖瓣生物假体。根据两阶段植入（异种心包 26 毫米框架生物假体的初次植入和开发的 23 毫米生物假体的再植入）的结果，揭示了定量指标的微小变化：经假体梯度增加了 1.3 毫米汞柱二尖瓣口面积减少21.6%。干预时间显着减少了 18 分钟（与主要假体相比减少了 40%）。动物没有不良事件和术后并发症，以及生理血流动力学指标表明开发的医疗器械是安全的。