We studied activities of antioxidant system enzymes in tissues of rats with experimental allergic encephalomyelitis. It was shown that the development of pathology is accompanied by deformation of the neurons and axonal degeneration, intensification of free radical oxidation, exhaustion of the reduced glutathione pool, and multidirectional changes in activities of antioxidant enzymes in rat tissues. The observed imbalance in the antioxidant defense system can be associated with excessive glutathione utilization in the glutathione transferase reaction and different severity of the pathological process in the brain and spinal cord. The received data necessitate the search for compounds that can prevent inhibition of antioxidant system components in order to analyze the possibility of their use in the treatment of multiple sclerosis.

中文翻译：

---

实验性变态反应性脑脊髓炎大鼠抗氧化防御酶的活性

我们研究了实验性过敏性脑脊髓炎大鼠组织中抗氧化系统酶的活性。结果表明，病理学的发展伴随着大鼠组织中神经元变形和轴索变性、自由基氧化加剧、还原型谷胱甘肽池耗竭以及抗氧化酶活性的多向变化。观察到的抗氧化防御系统的不平衡可能与谷胱甘肽转移酶反应中过度利用谷胱甘肽以及大脑和脊髓中不同严重程度的病理过程有关。收到的数据需要寻找可以防止抗氧化系统成分受到抑制的化合物，以便分析它们用于治疗多发性硬化症的可能性。