The study compared antituberculous efficacy of individual or combined administration of “free” isoniazid and liposomal form of dextrazide (a composition consisted of isoniazid and oxidized dextran) inhaled in standard (15 mg/kg) or low (3 mg/kg) dose. The therapy started 1 month after contamination of outbred ICR male mice with Mycobacterium tuberculosis strain H37Rv. Combined inhalation of liposomal form of dextrazide and isoniazid in the low dose was most effective against mycobacterium tuberculosis due to diminished prodestructive pulmonary effect and a low hepatotoxicity. A minor prodestructive effect of this combination was observed starting from 1.5 month after the onset of therapy (12 inhalations, 2 times a week), and it augmented after 24 inhalations administered during 3 months.

中文翻译：

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不同时间长度的实验治疗过程对小鼠抗结核组合物的吸入效果

该研究比较了以标准 (15 mg/kg) 或低 (3 mg/kg) 剂量吸入“游离”异烟肼和脂质体形式的右旋肼（一种由异烟肼和氧化葡聚糖组成的组合物）单独或联合给药的抗结核疗效。该疗法在远交 ICR 雄性小鼠被结核分枝杆菌菌株 H37Rv 污染后 1 个月开始。联合吸入脂质体形式的右旋肼和异烟肼低剂量对结核分枝杆菌最有效，因为对肺的破坏作用减弱，肝毒性低。从治疗开始后 1.5 个月开始观察到这种组合的轻微破坏作用（12 次吸入，每周 2 次），并在 3 个月内进行 24 次吸入后增强。