Purpose: Investigation of the acute effects of cigarette smoking on the eye using optical coherence tomography angiography (OCTA) on young healthy non-smoking male subjects.Materials and methods: The right eye of 25 healthy non-smoking male subjects were included in this study. Selected parameters of the macular and circumpapillary vasculature were measured, including macular flow indices, foveal avascular zone, vessel densities of macula and optic disc using OCTA. The measurements of the subjects were performed on the first day without smoking at 0 min, 5 min, 30 min and 60 min. Measurements were repeated at the same regime on the second day after smoking. Paired samples t-test and repeated measures one-way analysis of variance test was used for the statistical analysis.Results: The repeated measures analysis of variance test using the Bonferroni adjustment demonstrated a significant change for superficial and deep foveal vessel density, flow area of choriocapillaris, and circumpapillary capillary density following smoking (range of p value was <0.001-0.004). Intraocular pressure, foveal avascular zone area, flow area of outer retina and foveal non-flow area of superficial layer measurements did not have any significant changes following smoking (range of p value was 0.192-0.812).Conclusion: In non-smoking cases, even smoking only one cigarette significantly decreased the vessel density parameters at the acute period. Even though there was an increase in measured parameters shortly after smoking, it had lessened when compared to non-smokers, even one hour following smoking.

中文翻译：

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通过光学相干断层扫描血管造影评估吸烟对非吸烟健康年轻男性受试者眼睛的急性影响。

目的：通过光学相干断层扫描血管造影（OCTA）研究吸烟对年轻健康非吸烟男性受试者的眼睛的急性影响。材料与方法：本研究纳入了25名健康非吸烟男性受试者的右眼。使用OCTA测量了黄斑和乳头周围血管的选定参数，包括黄斑流量指数，小凹无血管区域，黄斑的血管密度和视盘。在第一天在0分钟，5分钟，30分钟和60分钟不吸烟的情况下进行受试者的测量。吸烟后第二天在相同的治疗方案下重复测量。统计分析采用配对样本t检验和重复测量单因素方差分析进行。使用Bonferroni校正对方差检验进行的重复测量分析表明，吸烟后浅表和深凹的中心凹血管密度，脉络膜毛细血管通过面积和乳头周围毛细血管密度发生了显着变化（p值<0.001-0.004）。吸烟后眼压，中央凹无血管区域面积，视网膜外流面积和浅表凹中央无流量面积无明显变化（p值范围为0.192-0.812）。结论：在非吸烟病例中，即使是只抽一支烟，在急性期也显着降低了血管密度参数。即使在吸烟后不久测量的参数有所增加，但与不吸烟者相比，即使吸烟后一小时，测量值的下降也有所减少。