Abstract Dental plaque is a biofilm composed of a complex oral microbial community. The accumulation of plaque in the pit and fissures of dental elements often leads to the development of tooth decay (dental caries). Here, potent anti-biofilm materials were developed by incorporating zinc methacrylates or di-n-butyl-dimethacrylate-tin into the light-curable sealant and their physical, mechanical, and biological properties were evaluated. The data revealed that 5% di-n-butyl-dimethacrylate-tin (SnM 5%) incorporated sealant showed strong anti-biofilm efficacy against various single-species (Streptococcus mutans or Streptococcus oralis or Candida albicans) and S. mutans-C. albicans cross-kingdom dual-species biofilms without either impairing the mechanical properties of the sealant or causing cytotoxicities against mouse fibroblasts. The findings indicate that the incorporation of SnM 5% in the experimental pit and fissure self-adhesive sealant may have the potential to be part of current chemotherapeutic strategies to prevent the formation of cariogenic oral biofilms that cause dental caries.

中文翻译：

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金属单体改性新型窝沟自粘封闭剂的抗生物膜活性


摘要 牙菌斑是由复杂的口腔微生物群落组成的生物膜。牙菌斑在牙体的凹坑和裂隙中积聚，通常会导致蛀牙（龋齿）的发生。在这里，通过将甲基丙烯酸锌或二甲基丙烯酸二正丁酯锡掺入光固化密封剂中开发了有效的抗生物膜材料，并评估了它们的物理、机械和生物性能。数据显示，掺有 5% 二甲基丙烯酸二正丁酯锡 (SnM 5%) 的密封剂对各种单一物种（变形链球菌、口腔链球菌或白色念珠菌）和变形链球菌-C 表现出强大的抗生物膜功效。白色念珠菌跨界双物种生物膜，既不损害密封剂的机械性能，也不引起针对小鼠成纤维细胞的细胞毒性。研究结果表明，在实验性窝沟自粘封闭剂中加入 5% SnM 可能有可能成为当前化疗策略的一部分，以防止形成导致龋齿的致龋口腔生物膜。