Introduction

Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to exert numerous beneficial health effects in the body. High-Intensity Interval Exercise (HIIT) is a form of interval training that provides improved athletic capacity and has a protective effect on health. The purpose of this study was to investigate the interactive effects of swimming HIIT and Resveratrol supplementation on behavioral function in Novel object recognition and open-field tests in aged rats.

Methods

A total of 45 aged male Wistar rats with an age of 20 months were randomly assigned into five groups of control (C), swimming HIIT (SW-HIIT), swimming HIIT with Resveratrol supplementation (SW-HIIT-R), Resveratrol supplementation (R), and solvent of Resveratrol supplementation (SR). There was also another group that included young animals (2-month-old) and was used to compare with older animals. Swimming HIIT and Resveratrol supplementation groups performed the exercise and received Resveratrol (10 mg/kg/day, gavage) for six weeks. Novel object recognition and open-field tests were used for evaluating the behavioral functions in animals.

Results

The results showed that HIIT and Resveratrol significantly improved recognition memory compared to old animals. Moreover, it seems that HIIT and Resveratrol partly could modulate anxiety-like behaviors compared to old animals in the open-field test.

中文翻译：

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白藜芦醇和游泳HIIT锻炼对老年大鼠新型物体识别和野外任务的联合作用。

介绍

据报道，白藜芦醇是一种富含葡萄和红酒的天然多酚，可对人体产生多种有益健康的作用。高强度间歇锻炼（HIIT）是一种间歇训练形式，可提高运动能力并对健康产生保护作用。这项研究的目的是调查游泳HIIT和白藜芦醇补充对老年大鼠的新型物体识别和开放视野测试中行为功能的相互作用。

方法

将45只20个月大的雄性Wistar雄性大鼠随机分为5组，分别为对照组（C），游泳HIIT（SW-HIIT），游泳加白藜芦醇（SW-HIIT-R），白藜芦醇补充（ R）和白藜芦醇补充剂（SR）的溶剂。还有另一组包括幼小的动物（2个月大），用来与年龄较大的动物进行比较。游泳HIIT和白藜芦醇补充组进行了锻炼，并接受白藜芦醇（10毫克/千克/天，管饲）六周。新颖的物体识别和野外测试被用于评估动物的行为功能。

结果

结果表明，与老年动物相比，HIIT和白藜芦醇可显着改善识别记忆。而且，与野外试验中的老年动物相比，HIIT和白藜芦醇似乎可以部分调节焦虑样行为。