To introduce the concept of cognitive intolerance. A test is proposed to measure this concept and pilot data are presented to support this measure and future research to develop this concept into a construct. Research design: Three-group comparison to protect larger study blinding. Methods and procedures: Two groups of student athletes (n = 13, n = 13) between 13 and 17 (mean 15.1 ± 1.1 years; 58% male) who sustained a sport-related concussion within 10 days and one group (n = 13) of age-matched healthy controls were recruited for a comparison of correlations between self and observer ratings of cognitive difficulties and DTI fractional anisotropy (FA) using tract-based spatial statistics (TBSS) analysis at two time points. Main outcomes and results: Significant negative only associations (higher cognitive difficulty and lower FA) with DTI FA were found in white matter tracts. These included the anterior corpus callosum, frontal-parietal longitudinal fasciculi, and cortical-subcortical pathways at only the second time point. Several working memory networks would likely involve connections using the above-identified white matter tracts. Conclusions: Cognitive intolerance can be defined as symptom exacerbation from prolonged cognitive activity. Cognitive intolerance could be measured by the n-back working memory task and time to symptom exacerbation.

中文翻译：

---

对脑震荡后重返校园的青少年的认知不耐受和神经影像学的初步调查。

介绍认知不宽容的概念。提出了一个测试该概念的测试，并提供了试验数据来支持该测量，并进行了进一步的研究以将该概念发展为一个构想。研究设计：三组比较，以保护更大的研究盲目性。方法和程序：两组学生运动员（n = 13，n = 13）在13到17岁之间（平均15.1±1.1岁； 58％的男性），在10天内遭受了与运动相关的脑震荡，另一组（n = 13） ）招募了年龄匹配的健康对照者，以便在两个时间点使用基于片段的空间统计量（TBSS）分析比较自我和观察者的认知困难等级与DTI分数各向异性（FA）之间的相关性。主要结果和结果：在白质道中发现与DTI FA显着负相关（较高的认知难度和较低的FA）。这些包括仅在第二个时间点的体前,、额顶顶纵束和皮质-皮层下通路。几个工作内存网络可能会涉及使用上述白质束的连接。结论：认知不宽容可以定义为长时间的认知活动导致的症状加重。认知不耐受可以通过n背工作记忆任务和症状加重时间来衡量。几个工作内存网络可能会涉及使用上述白质束的连接。结论：认知不宽容可以定义为长时间的认知活动导致的症状加重。认知不耐受可以通过n背工作记忆任务和症状加重时间来衡量。几个工作内存网络可能会涉及使用上述白质束的连接。结论：认知不宽容可以定义为长时间的认知活动导致的症状加重。认知不耐受可以通过n背工作记忆任务和症状加重时间来衡量。